Immobilized Triazine-Type Dehydrocondensing Reagents for Carboxamide Formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl

Kazuhito Hioki; Satomi Kameyama; Shohei Tani; Munetaka Kunishima

doi:10.1248/cpb.55.825

Notes

Immobilized Triazine-Type Dehydrocondensing Reagents for Carboxamide Formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl

Kazuhito Hioki, Satomi Kameyama, Shohei Tani, Munetaka Kunishima

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Keywords: triazine, immobilized reagent, dehydrocondensation, ring opening metathesis polymerization (ROMP), amide

JOURNAL FREE ACCESS

2007 Volume 55 Issue 5 Pages 825-828

DOI https://doi.org/10.1248/cpb.55.825

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Abstract

New triazine-type dehydrocondensing reagents, such as ROMP-Trz-Cl and ROMP(OH)-Trz-Cl, were synthesized by a ring opening metathesis polymerization (ROMP) method, and these showed higher loading than conventional polymer-supported condensing reagents. These polymers effect the formation of amides in good yields by addition of a mixture of carboxylic acid, amine and NMM. ROMP(OH)-Trz-Cl, which contains hydroxyl groups in the polymer chain, gave amides in good yields even in MeOH.

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