Hydroperoxysterols from the Tunicate Eudistoma sp.

Ping-Jyun Sung; Mei-Ru Lin; Jih-Jung Chen; Shen-Fan Lin; Yang-Chang Wu; Tsong-Long Hwang; Lee-Shing Fang

doi:10.1248/cpb.55.666

Notes

Hydroperoxysterols from the Tunicate Eudistoma sp.

Ping-Jyun Sung, Mei-Ru Lin, Jih-Jung Chen, Shen-Fan Lin, Yang-Chang Wu, Tsong-Long Hwang, Lee-Shing Fang

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Keywords: tunicate, Eudistoma, hydroperoxysterol, cytotoxicity, human neutrophil elastase

JOURNAL FREE ACCESS

2007 Volume 55 Issue 4 Pages 666-668

DOI https://doi.org/10.1248/cpb.55.666

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Abstract

Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.

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