Enantioselective Synthesis of Pachastrissamine (Jaspin B) Using Dirhodium(II)-Catalyzed C–H Amination and Asymmetric Dihydroxylation as Key Steps

Takayuki Yakura; Seiichi Sato; Yuya Yoshimoto

doi:10.1248/cpb.55.1284

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Enantioselective Synthesis of Pachastrissamine (Jaspin B) Using Dirhodium(II)-Catalyzed C–H Amination and Asymmetric Dihydroxylation as Key Steps

Takayuki Yakura, Seiichi Sato, Yuya Yoshimoto

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Keywords: pachastrissamine, total synthesis, C–H amination, jaspin B, dirhodium(II), asymmetric dihydroxylation

JOURNAL FREE ACCESS

2007 Volume 55 Issue 8 Pages 1284-1286

DOI https://doi.org/10.1248/cpb.55.1284

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Abstract

Enantioselective total synthesis of anhydrophytosphingosine pachastrissamine (jaspin B) was achieved using Sharpless asymmetric dihydroxylation and dirhodium(II)-catalyzed C–H amination as key steps.

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