Fungal Metabolites. XVI. Structures of New Peptaibols, Trichokindins I-VII, from the Fungus Trichoderma harzianum

Akira IIDA; Masaki SANEKATA; Tetsuro FUJITA; Hiromi TANAKA; Akio ENOKI; Goro FUSE; Michiko KANAI; Patrick J. RUDEWICZ; Eiichi TACHIKAWA

doi:10.1248/cpb.42.1070

Akira IIDA, Masaki SANEKATA, Tetsuro FUJITA, Hiromi TANAKA, Akio ENOKI, Goro FUSE, Michiko KANAI, Patrick J. RUDEWICZ, Eiichi TACHIKAWA

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Keywords: Trichoderma harzianum, peptaibol, catecholamine, α-aminoisobutyric acid, isovaline, amino alcohol

JOURNAL FREE ACCESS

1994 Volume 42 Issue 5 Pages 1070-1075

DOI https://doi.org/10.1248/cpb.42.1070

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Abstract

New peptaibols, trichokindins I-VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca²⁺-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells.

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