Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Marine Natural Products. XXVIII. The Structures of Sarasinosides A1, A2, A3, B1, B2, B3, C1, C2, and C3, Nine New Norlanostane-Triterpenoidal Oligoglycosides from the Palauan Marine Sponge Asteropus sarasinosum
Motomasa KOBAYASHIYoshihiro OKAMOTOIsao KITAGAWA
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1991 Volume 39 Issue 11 Pages 2867-2877

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Abstract

The chemical structures of sarasinosides A1, A2, A3, B1, B2, B3, C1, C2, and C3, nine 30-norlanostane-triterpenoidal oligoglycosides isolated from the Palauan marine sponge Asteropus sarasinosum have been elucidated on the basis of chemical and physicochemical evidence. Sarasinosides A2 (2) and A3 (3) were shown to be the 7, 9(11)-diene and 8, 14-diene analogs of sarasinoside A1 (1), whereas sarasinosides B2 (7) and B3 (9) were the 7, 9(11)-diene and 8, 14-diene analogs of sarasinoside B1 (5), respectively. Similar structural correlations of sarasinosides C2 (6) and C3 (8) with sarasinoside C1 (4) were demonstrated. These sarasinosides characteristically contain one mole each of N-acetyl-glucosamine and N-acetylgalactosamine in their oligosaccharide moieties.

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© The Pharmaceutical Society of Japan
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