EFFICIENT ENZYMATIC PREPARATION OF (+)- AND (-)-COREY LACTONE DERIVATIVES

Tsutomu SUGAHARA; Ikuko SATOH; Osamu YAMADA; Seiichi TAKANO

doi:10.1248/cpb.39.2758

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

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Volume 39 (1991) Issue 10
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EFFICIENT ENZYMATIC PREPARATION OF (+)- AND (-)-COREY LACTONE DERIVATIVES

Tsutomu SUGAHARA, Ikuko SATOH, Osamu YAMADA, Seiichi TAKANO

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Keywords: Corey lactone, lipase PS, lipase AK, enzymatic transesterification, enzymatic hydrolysis

JOURNAL FREE ACCESS

1991 Volume 39 Issue 10 Pages 2758-2760

DOI https://doi.org/10.1248/cpb.39.2758

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Abstract

Two pairs of Corey lactone derivatives, (+)-1, (-)-2 and (+)-3, (-)-4 have been efficiently prepared in high optical purity by enzymatic esterification and enzymatic hydrolysis catalyzed by lipases from Pseudomonas sp.

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