Studies on Macrocyclic Lactone Antibiotics. V. The Structures of Azalomycins F3a and F5a

SHIGEO IWASAKI; MICHIO NAMIKOSHI; KEIZO SASAKI; KAZUTAKA FUKUSHIMA; SHIGENOBU OKUDA

doi:10.1248/cpb.30.4006

Studies on Macrocyclic Lactone Antibiotics. V. The Structures of Azalomycins F_3a and F_5a

SHIGEO IWASAKI, MICHIO NAMIKOSHI, KEIZO SASAKI, KAZUTAKA FUKUSHIMA, SHIGENOBU OKUDA

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Keywords: malonic acid hemiester

JOURNAL FREE ACCESS

1982 Volume 30 Issue 11 Pages 4006-4014

DOI https://doi.org/10.1248/cpb.30.4006

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Abstract

The structures of the antibiotics azalomycin F_3a (1b) (C₅₅H₉₃N₃O₁₇) and azalomycin F_5a (1c) (C₅₇H₉₇N₃O₁₇) were elucidated by comparison of their physicochemical properties with those of F_4a (1a) (C₅₆H₉₅N₃O₁₇). Structural differences among these three compounds lie only in their guanidine moieties, which have no methyl group, one methyl group and two methyl groups in F_3a, F_4a and F_5a, respectively.

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