Mitigation of Memory Impairment in Ovariectomized Rats Using Garlic Powder Treated with Subcritical Water

Akira Minami; Yasuyo Mikami; Takahiro Kano; Hiroshi Matsushita; Yuka Fujita; Marina Yoshimura; Yuki Abe; Hiromi Watanabe; Masaomi Hara; Yuki Kurebayashi; Tadanobu Takahashi; Hiroaki Kanazawa; Akihiko Wakatsuki; Takashi Suzuki

doi:10.1248/bpb.b19-00311

Notes

Mitigation of Memory Impairment in Ovariectomized Rats Using Garlic Powder Treated with Subcritical Water

Akira Minami, Yasuyo Mikami, Takahiro Kano, Hiroshi Matsushita, Yuka Fujita, Marina Yoshimura, Yuki Abe, Hiromi Watanabe, Masaomi Hara, Yuki Kurebayashi, Tadanobu Takahashi, Hiroaki Kanazawa, Akihiko Wakatsuki, Takashi Suzuki

Author information

Akira Minami
Department of Biochemistry, School of Pharmaceutical Sciences
Yasuyo Mikami
Department of Biochemistry, School of Pharmaceutical Sciences
Takahiro Kano
Department of Biochemistry, School of Pharmaceutical Sciences
Hiroshi Matsushita
Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
Yuka Fujita
Department of Biochemistry, School of Pharmaceutical Sciences
Marina Yoshimura
Department of Biochemistry, School of Pharmaceutical Sciences
Yuki Abe
Department of Biochemistry, School of Pharmaceutical Sciences
Hiromi Watanabe
Nikken Foods Co., Ltd.
Masaomi Hara
Nikken Foods Co., Ltd.
Yuki Kurebayashi
Department of Biochemistry, School of Pharmaceutical Sciences
Tadanobu Takahashi
Department of Biochemistry, School of Pharmaceutical Sciences
Hiroaki Kanazawa
Department of Functional Anatomy, School of Nursing, University of Shizuoka
Akihiko Wakatsuki
Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
Takashi Suzuki Corresponding author
Department of Biochemistry, School of Pharmaceutical Sciences

Keywords: garlic, subcritical water, memory impairment, depression, rat, postmenopausal syndrome

JOURNAL FREE ACCESS FULL-TEXT HTML

2020 Volume 43 Issue 3 Pages 546-549

DOI https://doi.org/10.1248/bpb.b19-00311

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Abstract

Women with estrogen deficiency are at the risk of suffering from neurological symptoms such as memory impairment. In the present study, we investigated the effect of garlic, Allium sativum L. (Asparagales: Amaryllidaceae), treated with subcritical water on memory impairment in ovariectomized (OVX) rats. OVX rats were administered garlic powder for 84 d. Hippocampus-dependent spatial memory was assessed using the Morris water maze test. Escape latency of the OVX rats increased compared with that of sham-operated rats. The prolonged escape latency of the OVX rats decreased to the level of that of sham-operated rats upon the administration of garlic powder (0.5% in feed). The weights of the body, uterus, and brain were not affected by the garlic powder administration. These results suggest that garlic powder treated with subcritical water mitigates memory impairment in OVX rats.

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