Multiple Combination of Angelica gigas Extract and Mesenchymal Stem Cells Enhances Therapeutic Effect

Ran Kim; Pilseog Kim; Chang Youn Lee; Seokyeon Lee; Hwayoung Yun; Min Young Lee; Jongmin Kim; Kyungmin Baek; Woochul Chang

doi:10.1248/bpb.b18-00193

Regular Articles

Multiple Combination of Angelica gigas Extract and Mesenchymal Stem Cells Enhances Therapeutic Effect

Ran Kim, Pilseog Kim, Chang Youn Lee, Seokyeon Lee, Hwayoung Yun, Min Young Lee, Jongmin Kim, Kyungmin Baek, Woochul Chang

Author information

Ran Kim
Department of Biology Education, College of Education, Pusan National University
Pilseog Kim
Department of Biology Education, College of Education, Pusan National University
Chang Youn Lee
Department of Integrated Omics for Biomedical Sciences, Yonsei University
Seokyeon Lee
Department of Biology Education, College of Education, Pusan National University
Hwayoung Yun
College of Pharmacy, Pusan National University
Min Young Lee
Department of Molecular Physiology, College of Pharmacy, Kyungpook National University
Jongmin Kim
Department of Life Systems, Sookmyung Women’s University
Kyungmin Baek
Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Daegu Hanny University
Woochul Chang Corresponding author
Department of Biology Education, College of Education, Pusan National University

Keywords: brain ischemic stroke, multiple combined treatment, Angelica gigas extract, mesenchymal stem cell

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2018 Volume 41 Issue 12 Pages 1748-1756

DOI https://doi.org/10.1248/bpb.b18-00193

Details

Abstract

Alternative medicines attract attention because stroke is rarely expected to make a full recovery with the most advanced medical technology. Angelica gigas (AG) is a well-known herbal medicine as a neuroprotective agent. The present study introduced mesenchymal stem cells (MSCs) to identify for the advanced treatment of the cerebrovascular disease. The objective of this research is validation of the enhanced effects of multiple combined treatment of AG extract with MSCs on stroke through angiogenesis. Our results confirmed that AG extract with MSCs improved the neovascularization increasing expression of angiogenesis-regulated molecules. The changes of brain and the behavioral ability showed the increased effects of AG extract with MSCs. As a result, AG extract and MSCs may synergistically increase the therapeutic potential by enhancing neovascularization. This mixed approach provides a new experimental protocol of herbal medicine therapy for the treatment of a variety of diseases including stroke, trauma, and spinal cord injury.

Graphical Abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!