Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line
Naofumi Seira, Naoki Yanagisawa, Akiko Suganami, Takuya Honda, Makiko Wasai, John W. Regan, Keijo Fukushima, Naoto Yamaguchi, Yutaka Tamura, Takayoshi Arai, Toshihiko Murayama, Hiromichi Fujino
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Keywords: indole compound, MW-03, prostaglandin E2, 15-hydroxyprostaglandin dehydrogenase, peroxisome proliferator-activated receptor-γ, colon cancer
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2017 Volume 40 Issue 10 Pages 1806-1812

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Abstract

Increases in the expression of prostaglandin E2 (PGE2) are widely known to be involved in aberrant growth in the early stage of colon cancer development. We herein demonstrated that the novel indole compound MW-03 reduced PGE2-induced cAMP formation by catalization to an inactive metabolite by inducing 15-hydroxyprostaglandin dehydrogenase through the activation of peroxisome proliferator-activated receptor-γ. MW-03 also inhibited colon cancer cell growth by arresting the cell cycle at the S phase. Although the target of MW-03 for cell cycle inhibition has not yet been identified, these dual anti-cancer effects of MW-03 itself and/or its leading compound(s) on colon cancer cells may reduce colon cancer development and, thus, have potential as a novel treatment for the early stage of this disease.

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© 2017 The Pharmaceutical Society of Japan
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