A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats

Yoichi Sunagawa; Hiromichi Wada; Hidetoshi Suzuki; Hiroki Sasaki; Atsushi Imaizumi; Hiroyuki Fukuda; Tadashi Hashimoto; Yasufumi Katanasaka; Akira Shimatsu; Takeshi Kimura; Hideaki Kakeya; Masatoshi Fujita; Koji Hasegawa; Tatsuya Morimoto

doi:10.1248/bpb.35.139

Regular Articles

A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats

Yoichi Sunagawa, Hiromichi Wada, Hidetoshi Suzuki, Hiroki Sasaki, Atsushi Imaizumi, Hiroyuki Fukuda, Tadashi Hashimoto, Yasufumi Katanasaka, Akira Shimatsu, Takeshi Kimura, Hideaki Kakeya, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto

Author information

Yoichi Sunagawa
Human Health Sciences, Graduate School of Medicine, Kyoto University
Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
Hiromichi Wada
Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
Hidetoshi Suzuki
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
Hiroki Sasaki
Theravalues Corporation
Atsushi Imaizumi
Theravalues Corporation
Hiroyuki Fukuda
Theravalues Corporation
Tadashi Hashimoto
Theravalues Corporation
Yasufumi Katanasaka
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
Akira Shimatsu
Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
Takeshi Kimura
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Hideaki Kakeya
Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
Masatoshi Fujita
Human Health Sciences, Graduate School of Medicine, Kyoto University
Koji Hasegawa
Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
Tatsuya Morimoto
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

Keywords: curcumin, drug delivery system, heart failure

JOURNAL FREE ACCESS

2012 Volume 35 Issue 2 Pages 139-144

DOI https://doi.org/10.1248/bpb.35.139

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Abstract

Curcumin is an inhibitor of p300 histone acetyltransferase activity, which is associated with the deterioration of heart failure. We reported that native curcumin, at a dosage of 50 mg/kg, prevented deterioration of the systolic function in rat models of heart failure. To achieve more efficient oral pharmacological therapy against heart failure by curcumin, we have developed a novel drug delivery system (DDS) which markedly increases plasma curcumin levels. At the dosage of 0.5 mg/kg, DDS curcumin but not native curcumin restored left ventricular fractional shortening in post-myocardial infarction rats. Thus, our DDS strategy will be applicable to the clinical setting in humans.

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