Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity

Shin-ichi HAMADA; Takao KATAOKA; Je-Tae WOO; Atsushi YAMADA; Takashi YOSHIDA; Toshio NISHIMURA; Noboru OTAKE; Kazuo NAGAI

doi:10.1248/bpb.20.1017

Shin-ichi HAMADA, Takao KATAOKA, Je-Tae WOO, Atsushi YAMADA, Takashi YOSHIDA, Toshio NISHIMURA, Noboru OTAKE, Kazuo NAGAI

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Keywords: chebulagic acid, gallic acid, CTL, immunosuppression, tannin, Terminalia chebula

JOURNAL FREE ACCESS

1997 Volume 20 Issue 9 Pages 1017-1019

DOI https://doi.org/10.1248/bpb.20.1017

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Abstract

Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans : the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8⁺ CTL clone at IC₅₀ values of 30 μM and 50 μM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.

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