Expedient Synthesis of Mequitazine an Antihistaminic Drug by Palladium Catalyzed Allylic Alkylation of Sodium Phenothiazinate

Vanessa Gonnot; Marc Nicolas; Charles Mioskowski; Rachid Baati

doi:10.1248/cpb.57.1300

Notes

Expedient Synthesis of Mequitazine an Antihistaminic Drug by Palladium Catalyzed Allylic Alkylation of Sodium Phenothiazinate

Vanessa Gonnot, Marc Nicolas, Charles Mioskowski, Rachid Baati

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Keywords: antihistaminic drug, allylic alkylation, mequitazine, phenothiazine

JOURNAL FREE ACCESS

2009 Volume 57 Issue 11 Pages 1300-1302

DOI https://doi.org/10.1248/cpb.57.1300

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Abstract

A short and straightforward synthesis of the antihistaminic drug mequitazine is reported, based on an efficient palladium catalyzed allylic alkylation of 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate using sodium phenothiazinate in mild conditions.

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