Three New Compounds from Kadsura longipedunculata

Jian-Xin Pu; Xue-Mei Gao; Chun Lei; Wei-Lie Xiao; Rui-Rui Wang; Li-Bin Yang; Yong Zhao; Li-Mei Li; Sheng-Xiong Huang; Yong-Tang Zheng; Han-Dong Sun

doi:10.1248/cpb.56.1143

Regular Articles

Three New Compounds from Kadsura longipedunculata

Jian-Xin Pu, Xue-Mei Gao, Chun Lei, Wei-Lie Xiao, Rui-Rui Wang, Li-Bin Yang, Yong Zhao, Li-Mei Li, Sheng-Xiong Huang, Yong-Tang Zheng, Han-Dong Sun

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Jian-Xin Pu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xue-Mei Gao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Chun Lei
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Wei-Lie Xiao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Rui-Rui Wang
Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences
Li-Bin Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yong Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Li-Mei Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Sheng-Xiong Huang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yong-Tang Zheng
Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences
Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

Keywords: Kadsura longipedunculata, lignan, sesquiterpenoid, anti-human immunodeficiency virus activity

JOURNAL FREE ACCESS

2008 Volume 56 Issue 8 Pages 1143-1146

DOI https://doi.org/10.1248/cpb.56.1143

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Abstract

Two new tetrahydrofuran lignans, kadlongirins A and B (1, 2), a new cadinane-type sesquiterpenoid, 2,7-dihydroxy-11,12-dehydrocalamenene (3), together with seven known lignans, grandisin, fragransin B₁, vladirol F, kadsuralignan C, otobaphenol, isoanwulignan, and 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-phenol, were isolated from the leaves and stems of Kadsura longipedunculata. The structures of these new compounds were elucidated by spectroscopic methods. Compound 2 exhibited weak anti-human immunodeficiency virus-1 activity with an EC₅₀ value of 16.0 μg/ml, and therapeutic index (TI) value of 6.7.

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