New Rotenoids and Coumaronochromonoids from the Aerial Part of Boerhaavia erecta

Thi My Lien Do; Anh Vu Truong; Travis George Pinnock; Lawrence Michael Pratt; Shigeki Yamamoto; Hitoshi Watarai; Dominique Guillaume; Kim Phi Phung Nguyen

doi:10.1248/cpb.c12-01081

Regular Articles

New Rotenoids and Coumaronochromonoids from the Aerial Part of Boerhaavia erecta

Thi My Lien Do, Anh Vu Truong, Travis George Pinnock, Lawrence Michael Pratt, Shigeki Yamamoto, Hitoshi Watarai, Dominique Guillaume, Kim Phi Phung Nguyen

Author information

Thi My Lien Do
Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
Anh Vu Truong
Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
Travis George Pinnock
Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
Lawrence Michael Pratt
Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
Shigeki Yamamoto
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University
Hitoshi Watarai
Institute for Nanoscience Design, Osaka University
Dominique Guillaume
School of Pharmacy
Kim Phi Phung Nguyen Corresponding author
Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City

Keywords: Boerhaavia erecta, rotenoid, coumaronochromonoid, flavonoid

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Supplementary material

2013 Volume 61 Issue 6 Pages 624-630

DOI https://doi.org/10.1248/cpb.c12-01081

Details

Abstract

From the aerial part of Boerhaavia erecta L., three new rotenoids (3, 8, 10) and two new coumaronochromonoids (6, 11) were isolated, together with ten known compounds. The structure of the new compounds was established by one dimensional (1D)- and 2D-NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of compound 11 was determined by UV circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Rotenoids 3, 4 and 5 showed a strong cytotoxic activity against HeLa cell line and rotenoids 5 and 8 showed good activity against MCF-7 cell line.

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