Four New ent-Kauranoids from Isodon rubescens var. lushanensis and Data Reassignment of Dayecrystal B

Hai-Bo Zhang; Jian-Xin Pu; Yuan-Yuan Wang; Fei He; Yong Zhao; Xiao-Nian Li; Xiao Luo; Wei-Lie Xiao; Yan Li; Han-Dong Sun

doi:10.1248/cpb.58.56

Regular Articles

Four New ent-Kauranoids from Isodon rubescens var. lushanensis and Data Reassignment of Dayecrystal B

Hai-Bo Zhang, Jian-Xin Pu, Yuan-Yuan Wang, Fei He, Yong Zhao, Xiao-Nian Li, Xiao Luo, Wei-Lie Xiao, Yan Li, Han-Dong Sun

Author information

Hai-Bo Zhang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Graduate School of Chinese Academy of Sciences
Jian-Xin Pu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yuan-Yuan Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Fei He
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Graduate School of Chinese Academy of Sciences
Yong Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xiao-Nian Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Graduate School of Chinese Academy of Sciences
Xiao Luo
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Graduate School of Chinese Academy of Sciences
Wei-Lie Xiao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yan Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

Keywords: Isodon rubescens var. lushanensis, ent-kauranoid, cytotoxicity

JOURNAL FREE ACCESS

2010 Volume 58 Issue 1 Pages 56-60

DOI https://doi.org/10.1248/cpb.58.56

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Abstract

Four new 7, 20-epoxy-ent-kauranoids, rubluanins A—D (1—4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2—14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 μM (IC₅₀) in U937 cells.

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