Notes
Cytotoxic Prenylated Flavonoids from the Stem Bark of Maackia amurensis
2009 Volume 57 Issue 3 Pages 302-306
Details
2009 Volume 57 Issue 3 Pages 302-306
Five new prenylated flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1—4, 6, 8—12 and 14—16 against four human cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC50 value of 7.8 μM against A375S2 and euchrenone b1 showed the most potent cytotoxicity with IC50 value of 4.5 μM against HeLa.
