Bis-(2-amino-5-selenazoyl) Ketone as a Superoxide Anion-Scavenger

Akihiro Sekiguchi; Atsuyoshi Nishina; Hirokazu Kimura; Ryo-hei Fukumoto; Masakazu Kogami; Hideharu Ishihara; Mamoru Koketsu

doi:10.1248/bpb.29.1404

Regular Articles

Bis-(2-amino-5-selenazoyl) Ketone as a Superoxide Anion-Scavenger

Akihiro Sekiguchi, Atsuyoshi Nishina, Hirokazu Kimura, Ryo-hei Fukumoto, Masakazu Kogami, Hideharu Ishihara, Mamoru Koketsu

Author information

Keywords: 2-amino-1,3-selenazole, heterocycle, superoxide radical, scavenging effect, superoxide anion-scavenging activities (SOSAs)

JOURNAL FREE ACCESS

2006 Volume 29 Issue 7 Pages 1404-1407

DOI https://doi.org/10.1248/bpb.29.1404

Details

Abstract

We investigated the superoxide anion scavenging effects of 2-amino-1,3- selenazoles and bis-(2-amino-5-selenazoyl) ketones using a highly sensitive quantitative chemiluminescence method. At 166 μM, the 2-amino-1,3-selenazoles and bis-(2-amino-5-selenazoyl) ketones scavenged in the range of 10.0 to 80.0% of O₂⁻. Bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone exhibited the strongest superoxide anion-scavenging activity among the six kinds of 2-amino-1,3-selenazoles and three kinds of bis-(2-amino-5-selenazoyl) ketones. The 50% inhibitory concentration (IC₅₀) of bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone was determined to be 37.1 μM. Thus, bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone acted in vitro as effective and potentially useful O₂⁻ scavenger.

Corresponding author

Register with J-STAGE for free!