Inhibition of Tyrosinase Activity by N,N-Unsubstituted Selenourea Derivatives

Sang Keun Ha; Mamoru Koketsu; Kunho Lee; Sang Yoon Choi; Ji-Ho Park; Hideharu Ishihara; Sun Yeou Kim

doi:10.1248/bpb.28.838

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Inhibition of Tyrosinase Activity by N,N-Unsubstituted Selenourea Derivatives

Sang Keun Ha, Mamoru Koketsu, Kunho Lee, Sang Yoon Choi, Ji-Ho Park, Hideharu Ishihara, Sun Yeou Kim

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Keywords: N,N-unsubstituted selenourea, tyrosinase inhibitor

JOURNAL FREE ACCESS

2005 Volume 28 Issue 5 Pages 838-840

DOI https://doi.org/10.1248/bpb.28.838

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Abstract

This study investigated inhibitory effects of N,N-unsubstituted selenourea derivatives on tyrosinase activity. Three types of N,N-unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3,4-dihydroxyphenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200 μM exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic acid (39.4%), a well known tyrosinase inhibitor. Moreover, the compound D identified as a noncompetitive inhibitor by Lineweaver–Burk plot analysis. In addition, compound D also inhibited the melanin production in melan-a cells.

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