Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Activation of the Aryl Hydrocarbon Receptor by Some Vegetable Constituents Determined Using in Vitro Reporter Gene Assay
Yoshiaki Amakura, Tomoaki Tsutsumi, Masafumi Nakamura, Hiroko Kitagawa, Junko Fujino, Kumiko Sasaki, Masatake Toyoda, Takashi Yoshida, Tamio Maitani
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Keywords: food, vegetable constituent, aryl hydrocarbon receptor, dioxin, chemical activated luciferase gene expression (CALUX) assay
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2003 Volume 26 Issue 4 Pages 532-539

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Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological action of many aromatic environmental pollutants. In this study, we investigated the activation of the AhR by some vegetable constituents using the AhR-based bioassay for dioxins, i.e., the chemical activated luciferase gene expression (CALUX) assay. Ninety-five vegetable constituents, including flavonoids, tannins, saponins, and terpenes, were tested in vitro. Among them, isoflavones such as daidzein, resveratrol having a stilbene structure, and some flavonoids such as naringenin, hesperetin, and baicalein showed AhR activation.

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© 2003 The Pharmaceutical Society of Japan
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