Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark

Intan Safinar Ismail; Hideyuki Ito; Teruo Mukainaka; Hiroshi Higashihara; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida

doi:10.1248/bpb.26.1351

Notes

Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark

Intan Safinar Ismail, Hideyuki Ito, Teruo Mukainaka, Hiroshi Higashihara, Fumio Enjo, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida

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Keywords: ichthyotoxic activity, Epstein-Barr virus early antigen (EBV-EA), koetjapic acid, Sandoricum koetjape, cancer chemoprevention

JOURNAL FREE ACCESS

2003 Volume 26 Issue 9 Pages 1351-1353

DOI https://doi.org/10.1248/bpb.26.1351

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Abstract

After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro, koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene and promoted by TPA.

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