Skip to main content
SpringerLink
Log in

Intensifying Neoadjuvant Therapy for Rectal Cancers Towards Watchful Waiting

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Huisman JF, Schoenaker IJH, Brohet RM, et al. Avoiding unnecessary major rectal cancer surgery by implementing structural restaging and a watch-and-wait strategy after neoadjuvant radiochemotherapy. Ann Surg Oncol. 2020. https://doi.org/10.1245/s10434-020-09192-0.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Francois Y, Nemoz CJ, Baulieux J, et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J Clin Oncol. 1999;17(8):2396. https://doi.org/10.1200/jco.1999.17.8.2396.

    Article  CAS  PubMed  Google Scholar 

  3. Bujko K, Wyrwicz L, Rutkowski A, et al. Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study. Ann Oncol. 2016;27(5):834–42. https://doi.org/10.1093/annonc/mdw062.

    Article  CAS  PubMed  Google Scholar 

  4. Chakrabarti D, Rajan S, Akhtar N, et al. Short-course radiotherapy with consolidation chemotherapy versus conventionally fractionated long-course chemoradiotherapy for locally advanced rectal cancer: a randomized clinical trial. Br J Surg. 2021. https://doi.org/10.1093/bjs/znab020.

    Article  Google Scholar 

  5. Chakrabarti D, Rajan S, Akhtar N, Qayoom S, Verma M, Gupta R. Dose escalated short-course radiotherapy in rectal cancers: is this the way forward? Ann Oncol. 2020;31:S93–S94. https://doi.org/10.1016/j.annonc.2020.04.096.

    Article  Google Scholar 

  6. Erlandsson J, Lörinc E, Ahlberg M, et al. Tumour regression after radiotherapy for rectal cancer: results from the randomised Stockholm III trial. Radiother Oncol. 2019;135:178–186. https://doi.org/10.1016/j.radonc.2019.03.016.

    Article  PubMed  Google Scholar 

  7. Ciseł B, Pietrzak L, Michalski W, et al. Long-course preoperative chemoradiation vs. 5 x 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study. Ann Oncol. 2019;30(8):1298–1303. https://doi.org/10.1093/annonc/mdz186.

    Article  PubMed  Google Scholar 

  8. Bahadoer RR, Dijkstra EA, van Etten B, et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2020;22(1):29–42. https://doi.org/10.1016/S1470-2045(20)30555-6.

    Article  PubMed  Google Scholar 

  9. Conroy T, Lamfichekh N, Etienne P-L, et al. Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiation in patients with locally advanced rectal cancer: final results of PRODIGE 23 phase III trial, a UNICANCER GI trial. J Clin Oncol. 2020;38(15 Suppl):4007. https://doi.org/10.1200/jco.2020.38.15_suppl.4007.

    Article  Google Scholar 

  10. Goodman KA. Total neoadjuvant therapy for rectal cancer. Cancer Radiother. 2018;22(5):459–465. https://doi.org/10.1016/j.canrad.2018.01.004.

    Article  CAS  PubMed  Google Scholar 

  11. Healey Bird BRJ. Total neoadjuvant therapy for locally advanced rectal cancer: the fuse is lit. Br J Surg. 2020;107(13):1705–707. https://doi.org/10.1002/bjs.12014.

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

The authors have no funding to declare.

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, King George’s Medical University, Lucknow, India

    Deep Chakrabarti MD, Rajeev Gupta MD & Madan Lal Brahma Bhatt MD

  2. Department of Surgical Oncology, King George’s Medical University, Lucknow, India

    Naseem Akhtar MS, MCh, Shiv Rajan MS, MCh, Vijay Kumar MCh & Arun Chaturvedi MS

  3. Department of Pathology, King George’s Medical University, Lucknow, India

    Sumaira Qayoom MD

Authors
  1. Deep Chakrabarti MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naseem Akhtar MS, MCh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shiv Rajan MS, MCh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumaira Qayoom MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vijay Kumar MCh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Arun Chaturvedi MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rajeev Gupta MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Madan Lal Brahma Bhatt MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naseem Akhtar MS, MCh.

Ethics declarations

Disclosures

Deep Chakrabarti, Naseem Akhtar, Shiv Rajan, Sumaira Qayoom, Vijay Kumar, Arun Chaturvedi, Rajeev Gupta, and Madan Lal Brahma Bhatt have no conflicts of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chakrabarti, D., Akhtar, N., Rajan, S. et al. Intensifying Neoadjuvant Therapy for Rectal Cancers Towards Watchful Waiting. Ann Surg Oncol 28, 4062–4063 (2021). https://doi.org/10.1245/s10434-020-09512-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-020-09512-4

Search

Navigation