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Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

A family history (FH) of colorectal cancer (CRC) increases the risk for development of CRC, but the impact of FH of CRC on survival from sporadic CRC is unclear. This study investigated the prognostic impact of FH of CRC on the recurrence and survival of patients with sporadic CRC.

Methods

We reviewed the records of patients with sporadic CRC from two tertiary referral hospitals in Korea who underwent surgical resection between May 2007 and September 2013. The clinicopathologic features and oncologic outcomes of those with and without FHs of CRC were compared.

Results

We examined the records of 2960 eligible patients, 163 (5.5%) of whom had first-degree relatives with CRC. Patients with and without FHs of CRC had similar baseline characteristics. Multivariable analysis indicated that a FH of CRC was not significantly associated with disease-free survival but was significantly associated with better overall survival (OS) [adjusted hazard ratio = 0.539, 95% confidence interval (CI) 0.330–0.881, P = 0.014]. Subgroup analysis indicated that females and rectal cancer patients with FHs of CRC had significantly better prognoses. Microsatellite status did not affect the improved survival rate associated with FH.

Conclusions

This study of patients with sporadic CRC indicated that those who had FHs of CRC had better OS but similar cancer recurrence as those who had no FH of CRC. The effect of FH of CRC on OS was independent of microsatellite status. Further studies are needed to identify underlying mechanisms and determine the optimal clinical management of CRC according to FH.

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Funding

This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant Number NRF-2017R1A2B4012238).

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Authors and Affiliations

  1. Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, Korea

    Soo Young Lee MD, PhD, Chang Hyun Kim MD, PhD, Hyeong Rok Kim MD, PhD & Young Jin Kim MD, PhD

  2. Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea

    Duck-Woo Kim MD, PhD, Sung Il Kang MD, Heung-Kwon Oh MD & Sung-Bum Kang MD, PhD

  3. Korean Hereditary Tumor Registry, Seoul National University College of Medicine, Seoul, Korea

    Duck-Woo Kim MD, PhD

  4. Department of Surgery, Soonchunhyang University Gumi Hospital, Gumi, Korea

    Myong Hoon Ihn MD

  5. Department of Surgery, Chonnam National University Hospital and Medical School, Gwangju, Korea

    Jae Kyun Ju MD, PhD

Authors
  1. Soo Young Lee MD, PhD
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  2. Duck-Woo Kim MD, PhD
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  3. Sung Il Kang MD
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  5. Heung-Kwon Oh MD
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  6. Sung-Bum Kang MD, PhD
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  7. Chang Hyun Kim MD, PhD
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  8. Hyeong Rok Kim MD, PhD
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Correspondence to Duck-Woo Kim MD, PhD.

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Lee, S.Y., Kim, DW., Kang, S.I. et al. Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer. Ann Surg Oncol 26, 1118–1126 (2019). https://doi.org/10.1245/s10434-019-07179-0

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  • DOI: https://doi.org/10.1245/s10434-019-07179-0

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