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Risk of Colorectal Cancer in Chronic Kidney Disease: A Matched Cohort Study Based on Administrative Data

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD.

Methods

The study cohort included patients aged ≥18 years diagnosed with CKD between 2004 and 2005 (n = 15,975). The comparison cohort (n = 79,875) included five randomly selected age- and gender-matched controls for each patient in the study cohort. All the subjects were followed up from the date of cohort entry until they developed CRC or until the end of 2006.

Results

We identified 15,975 patients with a diagnosis of CKD who matched the inclusion criteria. A total of 460 patients developed CRC during the study period, of whom 116 were from the CKD cohort and 344 were from the comparison cohort. After adjusting for potential confounding factors, the CKD patients not undergoing dialysis were independently associated with a greater risk of CRC (hazard ratio, 1.79; 95 % confidence interval [CI] 1.41–2.27). The overall incidence rate of CRC was 341 per 100,000 person-years for CKD patients not undergoing dialysis, compared to 174 per 100,000 person-years. The age-matched hazard ratio of CRC after excluding dialysis patients was 1.64 (95 % CI 1.27–2.11) in patients 50 years and older, and 3.7 (95 % CI 1.83–7.49) in patients younger than 50 years.

Conclusions

This population-based cohort study indicated that CKD patients not requiring dialysis have an increased risk of CRC compared to the general population, independent of comorbidities.

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Acknowledgment

This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by National Health Research Institutes and supported by the National Science Council of Taiwan under grant number 101-2118-M-031-001-MY2. The interpretation and conclusions contained herein do not represent those of Bureau of National Health Insurance, Department of Health or National Health Research Institutes.

Disclosure

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

    Mei-Yi Wu MD

  2. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Mei-Yi Wu MD & Tsu-Yi Chao MD

  3. Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

    Tung-Cheng Chang MD & Ming-Te Huang MD

  4. Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Tung-Cheng Chang MD & Ming-Te Huang MD

  5. Division of Hematology and Oncology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

    Tsu-Yi Chao MD

  6. Department of Mathematics, Soochow University, Taipei, Taiwan

    Hui-Wen Lin PhD

  7. Evidence Based Medicine Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

    Hui-Wen Lin PhD

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  1. Mei-Yi Wu MD
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  2. Tung-Cheng Chang MD
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  3. Tsu-Yi Chao MD
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  4. Ming-Te Huang MD
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Corresponding author

Correspondence to Hui-Wen Lin PhD.

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Wu, MY., Chang, TC., Chao, TY. et al. Risk of Colorectal Cancer in Chronic Kidney Disease: A Matched Cohort Study Based on Administrative Data. Ann Surg Oncol 20, 3885–3891 (2013). https://doi.org/10.1245/s10434-013-3065-8

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  • DOI: https://doi.org/10.1245/s10434-013-3065-8

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