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High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Hepatocellular carcinoma (HCC) has a high recurrence rate after resection. Abnormal activation of the sonic hedgehog (SHH) signaling pathway contributing to the carcinogenesis of some organs had been reported. We hypothesize that activation of SHH pathway contributes to the recurrence of HCC after surgical resection.

Methods

In a prospective study, from January 2006 to June 2010, a total of 50 consecutive patients with HCC after curative resection were enrolled. The ratio of the expression of messenger RNA (mRNA) of SHH, patched homolog-1 (PTCH-1) and glioma-associated oncogene-1 (GLI-1) between HCC tissues and the paired noncancerous liver tissues were measured. Both the clinicopathologic characteristics and these ratios were compared between those with recurrence and those without recurrence. They were also compared between those with and without survival.

Results

There was a statistically significant correlation among the ratios of PTCH-1 mRNA and serum AFP level (p = 0.045), tumor size (p = 0.001), vascular permeation (p = 0.043) and tumor, node, metastasis staging system (TNM) stage (p = 0.003). A borderline significant correlation was found among ratios of GLI-1 mRNA and tumor size (p = 0.062) and TNM stage (p = 0.051). There was no such significant correlation between SHH mRNA and any parameter. Both the ratios of PTCH-1 mRNA and GLI-1 mRNA significantly adversely affected recurrence (p = 0.003 and 0.005, respectively) and survival (p < 0.001 and <0.001, respectively).

Conclusions

Expression of PTCH-1 mRNA and GLI-1 mRNA in HCC tissues is a potential biomarker to predict postresection disease recurrence.

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Acknowledgment

Supported in part by Far Eastern Memorial Hospital and by financial support from a research grant of National Science Council. Executive Yuan, Taiwan, ROC (NSC-97-2314-B-418-008-MY3, Taiwan).

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Authors and Affiliations

  1. Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan

    Kuo-Shyang Jeng MD, FACS

  2. Department of Hepatogastroenterology, Chang-Gung Memorial Hospital, Linkou Medical Center, Chang-Gung University, Taoyuan, Taiwan

    I-Shyan Sheen MD & Wen-Juei Jeng MD

  3. Division of Gastroenterology, Far Eastern Memorial Hospital, Taipei, Taiwan

    Chien-Chu Lin MD & Chien-Kuan Lin MD

  4. Department of Mediated Research, Far Eastern Memorial Hospital, Taipei, Taiwan

    Jui-Chih Su MS, Ming-Che Yu MS & Hsin-Yi Fang BS

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  1. Kuo-Shyang Jeng MD, FACS
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  2. I-Shyan Sheen MD
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  3. Wen-Juei Jeng MD
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  4. Chien-Chu Lin MD
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  6. Jui-Chih Su MS
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  7. Ming-Che Yu MS
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Corresponding authors

Correspondence to I-Shyan Sheen MD or Wen-Juei Jeng MD.

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Jeng, KS., Sheen, IS., Jeng, WJ. et al. High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma. Ann Surg Oncol 20, 464–473 (2013). https://doi.org/10.1245/s10434-012-2593-y

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  • DOI: https://doi.org/10.1245/s10434-012-2593-y

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