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Cytokeratin 7 is a Predictive Marker for Survival in Patients with Esophageal Squamous Cell Carcinoma

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Patients diagnosed with stage II and III esophageal squamous cell carcinoma (ESCC) have variable prognosis. This group would benefit greatly from the discovery of prognostic markers that are capable of identifying individuals for whom adjuvant treatment would be advantageous. The aim of this study was to investigate the impact of immunohistochemically detected cytokeratin 7 (CK7) expression on disease-free survival, overall survival (OS), or therapeutic outcome in patients with ESCC.

Methods

Immunohistochemical analysis of CK7 was performed on 225 surgically resected specimens of stage 0–III ESCC.

Results

In total, 20 (9%) of 225 ESCC cases were positive for CK7. In stage 0–III ESCC patients, CK7 expression was statistically significantly associated with OS, independent of clinical covariates, including tumor, node, metastasis system stage. In stage II and III ESCC patients (n = 124), CK7 expression was significantly associated with poorer OS (P = 0.0377). Furthermore, in stage II and III ESCC patients who did not receive adjuvant chemotherapy (n = 73), CK7 expression was significantly associated with poorer OS (P = 0.0003). CK7 expression was not associated with therapeutic outcome in patients with stage II and III ESCC who received adjuvant chemotherapy. In patients with CK7-positive ESCC (n = 16), receipt of adjuvant chemotherapy tended to be beneficial for patients with stage II and III ESCC (P = 0.0654).

Conclusions

Immunohistochemical analysis of CK7 will help to identify high-risk patients.

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Acknowledgment

We thank Shinichi Norimura for his technical assistance and advice. This work was carried out with the cooperation of the Research Center for Molecular Medicine of the Faculty of Medicine of Hiroshima University. We thank the Analysis Center of Life Science of Hiroshima University for the use of their facilities. This work was supported in part by grants-in-aid for Cancer Research from the Ministry of Education, Culture, Science, Sports and Technology of Japan and in part by a grant-in-aid for the Third Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan, and by the National Institute of Biomedical Innovation (Program for Promotion of Fundamental Studies in Health Sciences) and by National Cancer Center Research and Development Fund.

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Authors and Affiliations

  1. Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

    Naohide Oue MD, PhD, Katsuhiro Anami MD, PhD, Naoya Sakamoto MD, PhD, Kazuhiro Sentani MD, PhD, Naohiro Uraoka MD & Wataru Yasui MD, PhD

  2. Center for Community Medicine, Division of Surgery, Oita University Faculty of Medicine, Yufu, Japan

    Tsuyoshi Noguchi MD, PhD

  3. Department of Surgery I, Oita University Faculty of Medicine, Yufu, Japan

    Seigo Kitano MD, PhD

  4. Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

    Kazuhiko Aoyagi PhD, Teruhiko Yoshida MD & Hiroki Sasaki PhD

Authors
  1. Naohide Oue MD, PhD
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  2. Tsuyoshi Noguchi MD, PhD
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  3. Katsuhiro Anami MD, PhD
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  4. Seigo Kitano MD, PhD
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  5. Naoya Sakamoto MD, PhD
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  6. Kazuhiro Sentani MD, PhD
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  7. Naohiro Uraoka MD
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  8. Kazuhiko Aoyagi PhD
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  9. Teruhiko Yoshida MD
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  10. Hiroki Sasaki PhD
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  11. Wataru Yasui MD, PhD
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Corresponding author

Correspondence to Wataru Yasui MD, PhD.

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Oue, N., Noguchi, T., Anami, K. et al. Cytokeratin 7 is a Predictive Marker for Survival in Patients with Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 19, 1902–1910 (2012). https://doi.org/10.1245/s10434-011-2175-4

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  • DOI: https://doi.org/10.1245/s10434-011-2175-4

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