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Prognostic Significance of CD151 Expression in Esophageal Squamous Cell Carcinoma with Aggressive Cell Proliferation and Invasiveness

  • Translational Research and Biomarkers
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Abstract

Background

CD151 is a member of the tetraspanins and has recently been reported as a promoter of the malignant progression of cancer. The purpose of this study was to clarify the clinicopathological outcome and prognostic significance of the immunohistochemical expression of CD151 in esophageal squamous cell carcinoma (ESCC).

Methods

We evaluated the significance of CD151 expression by immunohistochemistry in 138 surgically resected ESCC and the association of CD151 expression with clinicopathological features.

Results

Seventy-five (51.7%) ESCC showed a positive expression of CD151, which indicated a significant association with tumor depth (P = 0.004), lymph node metastasis (P = 0.002), distant metastasis (P = 0.025), and lymphatic invasion (P = 0.046), as well as the Ki-67 labeling index (P = 0.011). The 5-year survival rate of ESCC patients with CD151-positive expression was significantly lower than with CD151-negative expression (positive, 43.1%; negative, 63.8%; P = 0.003). Multivariate analysis showed that positive CD151 expression was not an independent factor for poor survival (P = 0.096).

Conclusions

CD151 expression is associated with tumor proliferation and invasiveness in ESCC.

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References

  1. Kato H, Fukuchi M, Miyazaki T, et al. Surgical treatment for esophageal cancer. Current issues. Dig Surg. 2007;24:88–95.

    Article  PubMed  Google Scholar 

  2. Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med. 2003;349:2241–52.

    Article  PubMed  CAS  Google Scholar 

  3. Stipp CS, Kolesnikova TV, Hemler ME. Functional domains in tetraspanin proteins. Trends Biochem Sci. 2003;28:106–12.

    Article  PubMed  CAS  Google Scholar 

  4. Yunta M, Lazo PA. Tetraspanin proteins as organisers of membrane microdomains and signalling complexes. Cell Signal. 2003;15:559–64.

    Article  PubMed  CAS  Google Scholar 

  5. Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005;6:801–11.

    Article  PubMed  CAS  Google Scholar 

  6. Berditchevski F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ. Analysis of the CD151-alpha3beta1 integrin and CD151-tetraspanin interactions by mutagenesis. J Biol Chem. 2001;276:41165–74.

    Article  PubMed  CAS  Google Scholar 

  7. Sridhar SC, Miranti CK. Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Oncogene. 2006;25:2367–78.

    Article  PubMed  CAS  Google Scholar 

  8. Hemler ME. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol. 2003;19:397–422.

    Article  PubMed  CAS  Google Scholar 

  9. Maecker HT, Todd SC, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J. 1997;11:428–42.

    PubMed  CAS  Google Scholar 

  10. Fitter S, Tetaz TJ, Berndt MC, Ashman LK. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. Blood. 1995;86:1348–55.

    PubMed  CAS  Google Scholar 

  11. Testa JE, Brooks PC, Lin JM, Quigley JP. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. Cancer Res. 1999;59:3812–20.

    PubMed  CAS  Google Scholar 

  12. Yauch RL, Berditchevski F, Harler MB, Reichner J, Hemler ME. Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell. 1998;9:2751–65.

    PubMed  CAS  Google Scholar 

  13. Sterk LM, Geuijen CA, van den Berg JG, Claessen N, Weening JJ, Sonnenberg A. Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo. J Cell Sci. 2002;115:1161–73.

    PubMed  CAS  Google Scholar 

  14. Takeda Y, Kazarov AR, Butterfield CE, et al. Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood. 2007;109:1524–32.

    Article  PubMed  CAS  Google Scholar 

  15. Ke AW, Shi GM, Zhou J, et al. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. Hepatology. 2009;49:491–503.

    Article  PubMed  CAS  Google Scholar 

  16. Yang XH, Richardson AL, Torres-Arzayus MI, et al. CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008;68:3204–13.

    Article  PubMed  CAS  Google Scholar 

  17. Gesierich S, Paret C, Hildebrand D, et al. Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res. 2005;11:2840–52.

    Article  PubMed  CAS  Google Scholar 

  18. Hashida H, Takabayashi A, Tokuhara T, et al. Clinical significance of transmembrane 4 superfamily in colon cancer. Br J Cancer. 2003;89:158–67.

    Article  PubMed  CAS  Google Scholar 

  19. Ang J, Lijovic M, Ashman LK, Kan K, Frauman AG. CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator? Cancer Epidemiol Biomarkers Prev. 2004;13:1717–21.

    PubMed  CAS  Google Scholar 

  20. Tokuhara T, Hasegawa H, Hattori N, et al. Clinical significance of CD151 gene expression in non-small cell lung cancer. Clin Cancer Res. 2001;7:4109–14.

    PubMed  CAS  Google Scholar 

  21. Sakai M, Kato H, Sano A, et al. Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Ann Surg Oncol. 2009;16:2494–501.

    Article  PubMed  Google Scholar 

  22. Sadej R, Romanska H, Baldwin G, et al. CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium. Mol Cancer Res. 2009;7:787–98.

    Article  PubMed  CAS  Google Scholar 

  23. Sano A, Kato H, Sakurai S, et al. CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma. Ann Surg Oncol. 2009;16:506–14.

    Article  PubMed  Google Scholar 

  24. Zoller M. Gastrointestinal tumors: metastasis and tetraspanins. Z Gastroenterol. 2006;44:573–86.

    Article  PubMed  CAS  Google Scholar 

  25. Kuwano H, Nakajima M, Miyazaki T, Kato H. Distinctive clinicopathological characteristics in esophageal squamous cell carcinoma. Ann Thorac Cardiovasc Surg. 2003;9:6–13.

    PubMed  Google Scholar 

  26. Youssef EM, Matsuda T, Takada N, et al. Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus. Cancer. 1995;76:358–66.

    Article  PubMed  CAS  Google Scholar 

  27. Klosek SK, Nakashiro K, Hara S, Shintani S, Hasegawa H, Hamakawa H. CD151 forms a functional complex with c-Met in human salivary gland cancer cells. Biochem Biophys Res Commun. 2005;336:408–16.

    Article  PubMed  CAS  Google Scholar 

  28. Bussolino F, Di Renzo MF, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol. 1992;119:629–41.

    Article  PubMed  CAS  Google Scholar 

  29. Saeki H, Oda S, Kawaguchi H, et al. Concurrent overexpression of Ets-1 and c-Met correlates with a phenotype of high cellular motility in human esophageal cancer. Int J Cancer. 2002;98:8–13.

    Article  PubMed  CAS  Google Scholar 

  30. Yang XH, Flores LM, Li Q, et al. Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res. 2010;70:2256–63.

    Article  PubMed  CAS  Google Scholar 

  31. Gibault L, Metges JP, Conan-Charlet V, et al. Diffuse EGFR staining is associated with reduced overall survival in locally advanced oesophageal squamous cell cancer. Br J Cancer. 2005;93:107–15.

    Article  PubMed  CAS  Google Scholar 

  32. Mimura K, Kono K, Hanawa M, et al. Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res. 2005;11:4898–904.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan

    Shigemasa Suzuki MD, Tatsuya Miyazaki MD, PhD, Naritaka Tanaka MD, PhD, Makoto Sakai MD, PhD, Akihiko Sano MD, PhD, Takanori Inose MD, PhD, Makoto Sohda MD, PhD & Hiroyuki Kuwano MD, PhD

  2. Department of Surgical Oncology, Dokkyo Medical University, Mibu, Tochigi, Japan

    Masanobu Nakajima MD, PhD & Hiroyuki Kato MD, PhD

Authors
  1. Shigemasa Suzuki MD
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  2. Tatsuya Miyazaki MD, PhD
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  3. Naritaka Tanaka MD, PhD
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  4. Makoto Sakai MD, PhD
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  5. Akihiko Sano MD, PhD
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  6. Takanori Inose MD, PhD
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  7. Makoto Sohda MD, PhD
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  8. Masanobu Nakajima MD, PhD
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  9. Hiroyuki Kato MD, PhD
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  10. Hiroyuki Kuwano MD, PhD
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Corresponding author

Correspondence to Shigemasa Suzuki MD.

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Suzuki, S., Miyazaki, T., Tanaka, N. et al. Prognostic Significance of CD151 Expression in Esophageal Squamous Cell Carcinoma with Aggressive Cell Proliferation and Invasiveness. Ann Surg Oncol 18, 888–893 (2011). https://doi.org/10.1245/s10434-010-1387-3

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  • DOI: https://doi.org/10.1245/s10434-010-1387-3

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