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Detection of Survivin-Expressing Circulating Cancer Cells (CCCs) in Peripheral Blood of Patients with Gastric and Colorectal Cancer Reveals High Risks of Relapse

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

We previously demonstrated that the detection of circulating cancer cells (CCCs) expressing survivin mRNA could provide valuable information for predicting metastasis and recurrence in breast cancer. The objective of this study was to investigate whether or not the detection of survivin expression in the peripheral blood could also have significant effects on the clinical outcomes of patients with gastric and colorectal cancer.

Methods

Survivin-expressing CCCs in peripheral blood samples obtained from 55 gastric cancer patients, 86 colorectal cancer patients, and 87 healthy volunteers were quantitatively examined by using a RT-PCR ELISA. Its clinical significance was statistically evaluated.

Results

The CCCs in the peripheral blood samples were detected in 45.4% and 44.0% of gastric and colorectal cancer patients, respectively. The presence of survivin-expressing CCCs was found to be significantly associated with the degree of tumor penetration, nodal status, and disease stages for both types of cancers. During a follow-up period of 36 months, patients who had a positive detection at the time of the initial assay test had a higher relapse rate than those who had a negative detection. As well, survivin-expressing CCCs were statistically shown to be a significant and independent predictor for cancer recurrence. The detection of survivin-expressing CCCs was also demonstrated to be more accurate in terms of predicting recurrence than traditional detection methods such as plasma carcinoembryonic antigen (CEA) measurements.

Conclusion

The detection of CCCs expressing survivin mRNA could be used to accurately identify gastric and colorectal cancer patients with high risks of relapse.

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Acknowledgment

This study was partially supported by grant from the Sichuan Provincial Department of Science and Technology (Grant. No. 416001004008).

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Authors and Affiliations

  1. Core Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, 32 Yi Huan Lu Xi Er Duan 610078, Chengdu, Sichuan, People’s Republic of China

    Shang-mian Yie PhD, Mei Cao PhD & Xu He PhD

  2. Chengdu Bio-Engineering Institute for Cancer Research, Chengdu, Sichuan, People’s Republic of China

    Shang-mian Yie PhD, Be Lou BS, Shang-rong Ye MD, Lin Rao BS, Sheng-min Wu BS, Hai-bo Xiao MS & En Gao BS

  3. Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu, Sichuan, People’s Republic of China

    Ping Li MD & Kang Hu MS

Authors
  1. Shang-mian Yie PhD
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  2. Be Lou BS
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  3. Shang-rong Ye MD
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  4. Mei Cao PhD
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  7. Kang Hu MS
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  9. Sheng-min Wu BS
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  10. Hai-bo Xiao MS
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Correspondence to Shang-mian Yie PhD.

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Yie, Sm., Lou, B., Ye, Sr. et al. Detection of Survivin-Expressing Circulating Cancer Cells (CCCs) in Peripheral Blood of Patients with Gastric and Colorectal Cancer Reveals High Risks of Relapse. Ann Surg Oncol 15, 3073–3082 (2008). https://doi.org/10.1245/s10434-008-0069-x

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  • DOI: https://doi.org/10.1245/s10434-008-0069-x

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