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Long-Term Results of Liver Resection for Non-colorectal, Non-neuroendocrine Metastases

  • Hepatic and Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Introduction

The safety and efficacy of liver resection for colorectal and neuroendocrine liver metastases is well established. However, there is lack of consensus regarding long-term effectiveness of hepatic resection for non-colorectal, non-neuroendocrine (NCNN) liver metastases.

Methods

A review of prospectively collected data of patients undergoing hepatic resection for NCNN liver metastases at two tertiary referral centres in the UK and Australia was undertaken. Survival analysis was used to evaluate the clinical, demographic and operative factors associated with long-term survival.

Results

A total of 114 hepatic resections in 102 patients were performed between 1986 and 2006. Postoperative mortality and morbidity was 0.8% and 21.1%, respectively. At 3 and 5 years overall survival was 56.1% and 38.5%, whereas disease-free survival was 37.2% and 26.5%, respectively. On multivariate analysis, factors associated with poor overall survival were diameter of liver metastasis [<5 cm versus >5 cm: hazard ratio (HR) = 2.83, p = 0.001] and the presence of extrahepatic nodal disease (HR = 3.58, p = 0.001). The type of tumor, the presence of distant extra-hepatic metastases, tumor-free interval, number and distribution of metastases did not effect long-term survival.

Conclusion

These results of the present study suggest that liver resection is an effective management option in selected patients with NCNN metastases confined to the liver.

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Acknowledgments

We wish to thank the hard work of our research assistants Jackie Mann and Glenda Balderson for coordinating patient follow-up and maintaining the prospective database for this study. We also acknowledge the support of the Pelican Cancer Foundation.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Basingstoke and North Hampshire Foundation Trust, Basingstoke, United Kingdom

    Thomas R. O’Rourke FRACS, Timothy G. John MD, FRCS (Ed), Fenella Welsh MD, FRCS & Myrddin Rees MS, FRCS

  2. Department of Hepatobiliary Surgery, Princess Alexandra Hospital, Brisbane, Australia

    Thomas R. O’Rourke FRACS, Shinn Yeung FRACS, Jonathan Fawcett DPhil, FRCS, FRACS, Stephen Lynch FRACS, Russell Strong CMG, FRACS, FACS, FRCS & Daryl Wall FRACS

  3. Department of Biosurgery and Surgical Technology, St Mary’s Hospital, Imperial College, London, United Kingdom

    Paris Tekkis MD, FRCS

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  1. Thomas R. O’Rourke FRACS
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  2. Paris Tekkis MD, FRCS
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  3. Shinn Yeung FRACS
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Correspondence to Myrddin Rees MS, FRCS.

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O’Rourke, T.R., Tekkis, P., Yeung, S. et al. Long-Term Results of Liver Resection for Non-colorectal, Non-neuroendocrine Metastases. Ann Surg Oncol 15, 207–218 (2008). https://doi.org/10.1245/s10434-007-9649-4

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  • DOI: https://doi.org/10.1245/s10434-007-9649-4

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