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Photodynamic Therapy With 5,10,15,20-Tetrakis(m-Hydroxyphenyl) Bacteriochlorin for Colorectal Liver Metastases Is Safe and Feasible: Results From a Phase I Study

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Abstract

Background

The prognosis for patients with liver metastases from colorectal carcinoma is limited because of the low number of patients who are eligible for curative hepatic resection. In this phase I study, 31 liver metastases in 24 patients with nonresectable metastases from colorectal carcinoma were treated with photodynamic therapy (PDT).

Methods

The photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC) was intravenously administered in a dose of .6 mg/kg (n = 12) or .3 mg/kg (n = 12). After 120 hours (n = 18) or 48 hours (n = 6), tumors were illuminated for 300 to 600 seconds through percutaneously inserted optical fibers with a light dose of 60 J/cm of diffuser (740 nm).

Results

Tumor necrosis at 1 month after PDT was achieved in all treated lesions. Laser treatment was associated with mild pain (n = 8) and transient subclinical hepatotoxicity (n = 21). In one patient, PDT damage to the pancreas was inflicted, and in another patient, PDT damage of the skin occurred, but no serious clinical complications from PDT were reported. Administration of .6 mg/kg of mTHPBC led to transient phlebitis in 10 patients, and 3 patients experienced mild skin phototoxicity after excess light exposure.

Conclusions

Colorectal liver metastases that are ineligible for resection can be safely and effectively treated with interstitial mTHPBC-based PDT.

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Authors and Affiliations

  1. Department of Surgery, K6-R, Leiden University Medical Center, Albinusdreef 2, 2300, RC, Leiden, The Netherlands

    Frederieke H. van Duijnhoven MD, PhD, Jeroen P. Rovers MD, PhD & Onno T. Terpstra MD, PhD, FRCS

  2. Diagnostische und Interventionelle Radiologie, Zentrum der Radiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

    Kerstin Engelmann MD & Thomas J. Vogl MD, PhD

  3. Department for Oncology and Radiotherapy, Clinical Hospital Osijek, Osijek, Croatia

    Zdenko Krajina MD, PhD

  4. Department of Surgery, The Royal London Hospital, London, United Kingdom

    Shaun F. Purkiss MS, FRCS

  5. Department of Medical Oncology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam, The Netherlands

    Frans A. N. Zoetmulder MD, PhD

Authors
  1. Frederieke H. van Duijnhoven MD, PhD
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  2. Jeroen P. Rovers MD, PhD
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  3. Kerstin Engelmann MD
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  4. Zdenko Krajina MD, PhD
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  5. Shaun F. Purkiss MS, FRCS
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  6. Frans A. N. Zoetmulder MD, PhD
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  7. Thomas J. Vogl MD, PhD
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  8. Onno T. Terpstra MD, PhD, FRCS
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Corresponding author

Correspondence to Onno T. Terpstra MD, PhD, FRCS.

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Published by Springer Science+Business Media, Inc. © 2005 The Society of Surgical Oncology, Inc.

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van Duijnhoven, F.H., Rovers, J.P., Engelmann, K. et al. Photodynamic Therapy With 5,10,15,20-Tetrakis(m-Hydroxyphenyl) Bacteriochlorin for Colorectal Liver Metastases Is Safe and Feasible: Results From a Phase I Study. Ann Surg Oncol 12, 808–816 (2005). https://doi.org/10.1245/ASO.2005.09.005

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  • DOI: https://doi.org/10.1245/ASO.2005.09.005

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