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RETRACTED ARTICLE: Hyaluronic Acid-Pluronic®F127-Laden Soft Contact Lenses for Corneal Epithelial Healing: In Vitro and In Vivo Studies

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This article was retracted on 26 August 2022

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Abstract

Hyaluronic acid (HA) is widely used to treat various ocular diseases like dry eye syndrome, keratoconus, and other corneal epithelial injuries. The currently available eye drop solutions need frequent doses affecting the routine life style of patients. In this work, the silicone contact lens was designed to entrap HA and Pluronic®F127 to improve the wettability of the contact lens to treat various ocular diseases. The soaking method (HA-SM) was compared with the direct entrapment (DL-HA-PI) technique. The HA-Pluronic®F127-laden contact lenses (DL-HA-PI) showed acceptable optical transmittance with improved swelling (water content) properties. The in vitro release data showed high burst release with HA-SM contact lenses (12–36 h), while DL-HA-PI contact lenses showed prolong release up to 96 h. The in vivo release in the rabbit tear fluid showed high HA concentration (tear fluid) with DL-HA-PI contact lenses in comparison to the HA-SM contact lenses. The DL-HA-PI-3 batch with Pluronic®F127 showed more promising results in schirmer strip study in comparison to DL-HA-3 batch (without Pluronic®F127). The presence of Pluronic®F127 with HA showed high potential to improve hydration property of the contact lens. The corneal healing model showed reduction in the ocular inflammatory symptoms with DL-HA-PI-3 batch, thus demonstrating the potential of HA and Pluronic®F127 to be used in various ocular diseases.

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Authors and Affiliations

  1. Department of Ophthalmology, The Second People’s Hospital of Jinan, No. 148, Jingyi Road, Huaiyin District, Jinan, 250022, Shandong Province, China

    Ning Wei & Chao Huang

  2. Refractive Surgery Center, The Second People’s Hospital of Jinan, No. 148, Jingyi Road, Huaiyin District, Jinan, 250022, Shandong Province, China

    Xianghui Xu & Lijun Cao

Authors
  1. Ning Wei
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  2. Xianghui Xu
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  4. Lijun Cao
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Correspondence to Lijun Cao.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1208/s12249-022-02400-y

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Wei, N., Xu, X., Huang, C. et al. RETRACTED ARTICLE: Hyaluronic Acid-Pluronic®F127-Laden Soft Contact Lenses for Corneal Epithelial Healing: In Vitro and In Vivo Studies. AAPS PharmSciTech 21, 162 (2020). https://doi.org/10.1208/s12249-020-01714-z

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