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Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets

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Abstract

Thermal extrusion (TE) 3D printing is a thermoplastic semisolid-based rapid prototyping process, which is capable of building complex structures. The aim of this study was to manufacture rapid-release puerarin tablets without solvent through TE 3D printing. Novel rapid-release tablets were fabricated with polyethylene glycol (PEG 4000) as the carrier at appropriate puerarin/PEG 4000 ratios, assessed through differential scanning calorimetry (DSC), solubility, and dissolution tests. The novel structures of 3D-printed tablets with five different values were formed by printing paths, which established a flexible way of adjusting in vitro drug release. An obvious acceleration (85% of cumulative release about 7.5 min at the soonest) was observed for the tablets with internal structural design. It was inferred that puerarin formed simple eutectic mixtures with PEG 4000 and that puerarin dispersed into the carrier based on DSC and X-Ray powder diffraction (XRD). This highlights the combined advantage of PEG as a soluble polymer with TE 3D printing and provides a suitable system for rapid puerarin release.

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Acknowledgments

We are grateful for the instruments purchased from Jingxin Pharmaceutical Co., Ltd. (Zhejiang, China).

Funding

This work was supported by National Science and Technology Major Project which belongs to “The research on the key technology of new drug delivery system and industrialization of new projects” (No. 2017ZX09201-003-011).

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Authors and Affiliations

  1. Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China

    Pingfei Li

  2. Department of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China

    Haoyue Jia, Shiming Zhang, Yining Yang, Haowei Sun, Haoyu Wang, Weisan Pan & Xinggang Yang

  3. Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Shenyang, 110042, China

    Fei Yin

  4. Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Shenyang, 110042, China

    Fei Yin

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  1. Pingfei Li
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Correspondence to Fei Yin or Xinggang Yang.

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Li, P., Jia, H., Zhang, S. et al. Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets. AAPS PharmSciTech 21, 20 (2020). https://doi.org/10.1208/s12249-019-1538-1

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