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Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery

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References

  1. G. M. Hall. Fentanyl and the metabolic response to surgery. Br. J. Anaesth. 52:561–562 (1980).

    Article  PubMed  CAS  Google Scholar 

  2. L. E. Mather. Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin. Pharmacokinet. 8:422–446 (1983).

    Article  PubMed  CAS  Google Scholar 

  3. R. K. Portenoy, and D. Lesage. Management of cancer pain. Lancet. 353:1695–1700 (1999).

    Article  PubMed  CAS  Google Scholar 

  4. G. Hanks, R. K. Portenoy, N. MacDonald, and K. Forbes. Difficult pain problems. Oxford textbook of palliative medicine, 2nd edn, Oxford University Press, Oxford, 1998.

    Google Scholar 

  5. P. J. Slattery, and R. A. Boas. Newer methods of delivery of opiates for relief of pain. Drugs. 30(6):539–551 (1985).

    Article  PubMed  CAS  Google Scholar 

  6. D. Harris, and J. R. Robinson. Drug delivery via the mucous membranes of the oral cavity. Pharm. Sci. 81:1–10 (1992).

    Article  CAS  Google Scholar 

  7. H. Zhang, J. Zhang, and J. B. Streisand. Oral mucosal drug delivery. Clinical pharmacokinetics and therapeutic applications. Clin. Pharmacokinet. 41:661–680 (2002).

    Article  PubMed  CAS  Google Scholar 

  8. S. Bredenberg, M. Duberg, B. Lennernas, H. Lennernas, A. Petterson, M. Westerberg, and C. Nystrom. In vitro and in vivo evaluation of a new sublingual tablet system for rapid oromucosal absorption using fentanyl citrate as the active substance. Eur. J Pharm. Sci. 20:327–334 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. J. B. Streisand, J. R. Varvel, D. R. Stanski, L. L. Mairc, M. A. Ashburn, B. I. Hague, S. D. Tarver, and T. H. Stanley. Absorption and bioavailability of oral transmucosal fentanyl citrate. Anesthesiology. 75:223–229 (1991).

    Article  PubMed  CAS  Google Scholar 

  10. A. M. Al-Ghananeem, A. H. Malkawi, and P. A. Crooks. Scopolamine sublingual spray: An alternative route of delivery for the treatment of motion sickness. Drug Dev. Ind. Pharm. 33(5):577–582 (2007).

    Article  PubMed  CAS  Google Scholar 

  11. J. Mannila, T. Jaervinen, K. Jaervinen, J. Tervonen, and P. Jarho. Sublingual administration of D9-tetrahydrocannabinol/b-cyclodextrin complex increases the bioavailability of D9-tetrahydrocannabinol in rabbits. Life Sci. 78(17):1911–1914 (2006).

    Article  PubMed  CAS  Google Scholar 

  12. A. M. Al-Ghananeem, A. H. Malkawi, and P. A. Crooks. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech. 7(1):E23 (2006).

    Article  PubMed  Google Scholar 

  13. D. S. Weinberg, C. E. Inturris B. Reidenberg et al. Sublingual absorption of selected opioids. Clin. Pharmacol. Ther. 44:335–342 (1988).

    PubMed  CAS  Google Scholar 

  14. D. A. Mclain, and C. C. Hug Jr. Intravenous fentanyl kinetics. Clin. Pharmacol. Ther. 28:106–114 (1980).

    Google Scholar 

  15. D. L. Mock, J. B. Streisand, B. Hague, R. R. Dzelzkalns, P. L. Baily, N. L. Pace, and T. H. Stanley. Transmucosal narcotic delivery: an evaluation of fentanyl (lollipop) premedication in man. Anesth. Analg. 65:5102 (1986).

    Google Scholar 

  16. K. Mystakidou, E. Katsouda, E. Tsilika, E. Parpa, and L. Vlahos. Transdermal therapeutic fentanyl-system (TTS-F). In Vivo. 18(5):633–642 (2004).

    PubMed  CAS  Google Scholar 

  17. M. J. Rathbone, R. Purves, F. A. Ghazali, and P. C. Ho. In vivo techniques for studying the oral mucosal absorption characteristics of drugs in animals and humans. In M. J. Rathbone (ed.), Oral mucosal drug delivery, Marcel Dekker, New York, 1996, pp. 121–156.

    Google Scholar 

  18. W. M. Dewell Jr, M. Khandaghabadi, M. J. D’Souza, and H. M. Solomon. High-performance liquid chromatographic determination of fentanyl and sufentanil returned from the operating room. Department of Pharmacy, Piedmont Hospital, Atlanta, GA 30309. Am. J. Hosp. Pharm. 50(11):2374–2375 (1993).

    PubMed  CAS  Google Scholar 

  19. M. Tsuchiya, W. Ueda, M. Tomoda, and M. Hirakawa. Determination of fentanyl concentrations in the blood with the application of high performance liquid chromatography. Department of Anesthesiology, Kochi Medical School, Nankoku Masui. The Japanese Journal of Anesthesiology. 40(4):644–6 (1991).

    CAS  Google Scholar 

  20. J. Schuttler, and P. F. White. Optimization of the radioimmunoassays for measuring fentanyl and alfentanil in human serum. Anesthesiology. 61(3):315–320 (1984).

    Article  PubMed  CAS  Google Scholar 

  21. G. Campistron, M. Giroux, J. C. Dumas, M. Hoff, R. Desprats, H. Grandjean, G. Pontonnier, and G. Houin. Fentanyl RIA improved by a single-step extraction. Unite de Pharmacocinetique Clinique, Unite INSERM 168, C.H.U., Toulouse, France. Clin. Chem. 34(10):2157 (1988).

    PubMed  CAS  Google Scholar 

  22. W. L. Wang, E. J. Cone, and J. Zacny. Immunoassay evidence for fentanyl in hair of surgery patients. Addiction Research Center, NIDA, Baltimore, MD 21224. Forensic Sci. Int. 61(1):65–72 (1993).

    Article  PubMed  CAS  Google Scholar 

  23. K. Kumar, D. J. Morgan, and D. P. Crankshaw. Determination of fentanyl and alfentanil in plasma by high-performance liquid chromatography with ultraviolet detection. School of Pharmaceutics, Victorian College of Pharmacy Ltd., Melbourne, Australia. J. Chromatogr. 419:464–468 (1987).

    Article  PubMed  CAS  Google Scholar 

  24. R. J. Woestenborghs, D. R. Stanski, J. C. Scott, and J. J. Heykants. Assay methods for fentanyl in serum: gas-liquid chromatography versus radioimmunoassay. Anesthesiology. 67(1):85–90 (1987).

    Article  PubMed  CAS  Google Scholar 

  25. J. M. Moore, A. C. Allen, D. A. Cooper, and S. M. Carr. Determination of fentanyl and related compounds by capillary gas chromatography with electron capture detection. Anal. Chem. 58(8):1656–60 (1986).

    Article  PubMed  CAS  Google Scholar 

  26. S. Bjorkman, and D. R. Stanski. Simultaneous determination of fentanyl and alfentanil in rat tissues by capillary column gas chromatography. Department of Anesthesia, Stanford University School of Medicine, CA 94305. J. Chromatogr. 433:95–104 (1988).

    Article  PubMed  CAS  Google Scholar 

  27. P. Kintz, P. Mangin, A. A. Lugnier, and A. J. Chaumont. Simultaneous determination of fentanyl and its major metabolites and fentanyl analogs using gas chromatography and nitrogen-selective detection. Inst. Med. Leg., Strasbourg. Fr. J. Chromatogr. 489(2):459–461 (1989).

    Article  PubMed  CAS  Google Scholar 

  28. S. Laganiere, L. Goernert, K. Gallicano, and R. Otson. Improved extraction, sensitivity, specificity, and stability for measuring fentanyl in plasma by gas chromatography with nitrogen detection. Clin. Chem. 39(10):2206–2207 (1993).

    PubMed  CAS  Google Scholar 

  29. J. R. Varvel, S. L. Shafer, S. S. Hwang, P. A. Coen, and D. R. Stanski. Absorption characteristics of transdermally administered fentanyl. Sch. Med., Stanford Univ., Stanford, CA, USA. Anesthesiology. 70(6):928–934 (1989).

    Article  PubMed  CAS  Google Scholar 

  30. R. K. Portenoy, M. A. Southam, S. K. Gupta, J. Lapin, M. Layman, C. E. Inturrisi, and K. M. Foley. Transdermal fentanyl for cancer pain. Repeated dose pharmacokinetics. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021. Anesthesiology. 78(1):36–43 (1993).

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

The authors wish to thank Insys Therapeutics, Inc. (Phoenix, AZ) for their support of this research.

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Authors and Affiliations

  1. College of Pharmacy, University of Kentucky, Lexington, Kentucky, 40536-0082, USA

    Ahmad H. Malkawi, Abeer M. Al-Ghananeem & Peter A. Crooks

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  1. Ahmad H. Malkawi
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  2. Abeer M. Al-Ghananeem
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  3. Peter A. Crooks
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Correspondence to Peter A. Crooks.

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Malkawi, A.H., Al-Ghananeem, A.M. & Crooks, P.A. Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery. AAPS J 10, 261–267 (2008). https://doi.org/10.1208/s12248-008-9031-x

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