Skip to main content
SpringerLink
Log in

Liposome formulation of NSC-639829 using halothane as a solvent: A technical note

  • Published:
AAPS PharmSciTech Aims and scope Submit manuscript

Conclusion

Halothane has been successfully used as a solvent for the liposome formulation of NSC-639829. Liposomes with similar morphology, particle size, incorporation efficiency, and stability were obtained with halothane, chloroform, and ether. Halothane provides additional ease in formulation because of its higher volatility and safety as compared with chloroform and ether. Halothane can be regarded as a safe alternative to chloroform or ether in liposome formulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13:238–252.

    Article  CAS  Google Scholar 

  2. Massing U, Fuxius S. Liposome formulations of anticancer drugs: selectivity and effectiveness. Drug Resist Updat. 2000;3:171–177.

    Article  CAS  Google Scholar 

  3. Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res. 1987;47:3039–3051.

    CAS  Google Scholar 

  4. Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissue. Microvasc Res. 1986;31:288–305.

    Article  CAS  Google Scholar 

  5. Budavari S. The Merck Index. 12th ed. Whitehouse Station, NJ: Merck and Co; 1996.

    Google Scholar 

  6. Verschueren K. Environmental Data. Handbook of Environmental Data on Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold; 1983: 178–179.

    Google Scholar 

  7. Ran Y, Yalkowsky SH. Halothane, a novel solvent for the preparation of liposomes containing 2-4′-amino-3′-methylphenyl benzothiazole (AMPB), an anticancer drug: a Technical Note. AAPS Pharm Sci Tech. 2003;4(2) article 20.

  8. Sax NI, Lewis RJ Sr. General Chemicals: Entries A-E. Dangerous Properties of Industrial Materials. 7th ed. New York, NY: Van Nostrand Reinhold; 1989: 1634–1635.

    Google Scholar 

  9. Medical Economics. Physicians' Desk Reference. 41st ed. Oradell, NJ: Medical Economics Co; 2002.

    Google Scholar 

  10. Occupational Safety and Health Administration. Chemical Sampling Information. Washington, DC: US Department of Labor, 1999.

    Google Scholar 

  11. Okada H, Kato M, Koyanagi T, Mizuno K. Synthesis and antitumor activity of water-soluble benzoylphenylureas. Chem Pharm Bull. 1999;47(3):430–433.

    CAS  Google Scholar 

  12. Jain N, Yang G, Tabibi ES, Yalkowsky SH. Solubilization of NSC-639829. Int J Pharm. 2001;225:41–47.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Pharmacy, The University of Arizona, 1703 E Mabel Street, Room #441, 85721, Tucson, AZ

    Akash Jain, Tapan Sanghvi & Samuel H. Yalkowsky

Authors
  1. Akash Jain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tapan Sanghvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Samuel H. Yalkowsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akash Jain.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jain, A., Sanghvi, T. & Yalkowsky, S.H. Liposome formulation of NSC-639829 using halothane as a solvent: A technical note. AAPS PharmSciTech 4, 52 (2003). https://doi.org/10.1208/pt040452

Download citation

  • Received:

  • Accepted:

  • DOI: https://doi.org/10.1208/pt040452

Keywords

Search

Navigation