Skip to main content
Log in

Freeze-drying of microparticulates in a vibro-separator

  • Published:
AAPS PharmSciTech Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Langer R. New method of drug delivery. Science. 1990;249:1527–1533.

    Article  CAS  Google Scholar 

  2. Mehta RC, Jeyanthi R, Calis S, Thanoo BC, Burton KW, DeLuca PP. Biodegradable microspheres as depot system for parenteral delivery of peptide drugs. J Contr Rel. 1994;29:375–384.

    Article  CAS  Google Scholar 

  3. Okada H, Doken Y, Ogawa Y, Toguchi H. Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers. Pharm Res. 1994;11(8):1143–1147.

    Article  CAS  Google Scholar 

  4. Bitter B, Morlock M, Koll H, Winter G, Kissel T. Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: Influence of the encapsulation technique and polymer purity on microsphere characteristics. Eur J Pharm Biopharm. 1998;45:295–305.

    Article  Google Scholar 

  5. Tracy MA. Development and scale-up of a microsphere protein delivery system. Biotechnol Prog. 1998;14:108–115.

    Article  CAS  Google Scholar 

  6. Hazrati AM, Jones BN, King KJ. Screening system. United States Patent 5,951,864 (1999).

  7. Young Y, Gerner F, Hazrati AM. Studying of the drying process of a powder in a Vibro-Separator. Pharm Eng. 1999;19:46–54.

    Google Scholar 

  8. Gerner F, Hazrati AM. A new technology to separate and dry solid content of slurries in pharmaceutical processes. Northeastern Chapter of the Institute for Pharmaceutical Engineering. 1999;1:12.

    Google Scholar 

  9. Hazrati AM, Gerner F. Purge-air drying of a wet cake on the vibrating screen of a vibro-filter dryer. Proc Interphex. 2000.

  10. Jo YW, Woo BH, Hazrati AM, DeLuca PP. Use of PharmASep unit for processing microspheres. AAPS PharmSciTech. 2001;2(1):Technical Note 2 (http://www.pharmscitech.com)

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Patrick P. DeLuca Ph.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Na, KH., Woo, B.H., Jo, Y.W. et al. Freeze-drying of microparticulates in a vibro-separator. AAPS PharmSciTech 2, Technical Note 3 (2001). https://doi.org/10.1208/pt0202_tn3

Download citation

  • Received:

  • Accepted:

  • DOI: https://doi.org/10.1208/pt0202_tn3

Keywords

Navigation