Abstract
Despite the epldemiologic coexistence of anemia and plumbism, the contribution of preexisting anemia to the risk for lead poisoning is incompletely defined. Rats were given oral lead, 54 mg/kg/day × 7. One group of 16 was made anemic (A) by bleeding off 25% of the blood volume on days 1, 3, and 5: sham phlebotomy was done on the same days in 12 non-anemic (NA) animals. Blood lead (Pb-B) and red cell lead (Pb-Rbc) were comparable until after day 5 when the hematocrit (Hct) of A dropped below 30%. At sacrifice on day 7 the comparable values, mean ± SE, were significantly different (*, p < .01) in the anemic (A) rats .
These generalized increases support an increased absorption of lead in anemia consistent with the clinical predilection to lead toxicity of children and adults with low levels of hemoglobin.
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Angle, C., Mcintire, M. EFFECT OF ANEMIA ON BLOOD AND TISSUE LEAD OF RATS. Pediatr Res 11, 433 (1977). https://doi.org/10.1203/00006450-197704000-00384
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DOI: https://doi.org/10.1203/00006450-197704000-00384