Journal of Lipid Research
Research ArticlesNovel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome
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This work was supported by United States Public Health Service (National Institutes of Health) Grants ES-013125 (N.A.P.), HD-064727 (N.A.P.), and EY-007361 (S.J.F.), National Science Foundation Grants CHE 0717067 (N.A.P.), and by an unrestricted grant from Research to Prevent Blindness (S.J.F.). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
- APCI
atmospheric pressure chemical ionization
- Chol
cholesterol
- COSY
correlation spectroscopy
- CYP46A1
cytochrome P450 46A1 (cholesterol 24-hydroxylase)
- 1D
one dimensional
- 7-DHC
7-dehydrocholesterol
- DHCEO
3β,5α-dihydroxycholest-7-en-6-one
- Dhcr7 or DHCR7
3β-hydroxysterol-Δ7-reductase
- EnP(5,8)
5α,8α-epidioxy-cholest-6-en-3β-ol
- HMBC
heteronuclear multiple bond correlation
- HSQC
heteronuclear single quantum correlation
- 7-kChol
7-ketocholesterol
- NOESY
nuclear Overhauser effect spectroscopy
- NP
normal-phase
- RP
reverse-phase
- SLOS
Smith-Lemli-Opitz syndrome
- SRM
selective reaction monitoring
- UV
ultraviolet
Abbreviations:
The online version of this article (available at http://www.jlr.org) contains supplementary data