Journal of Lipid Research
Research ArticlesTetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output
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Author contributions—L.L., A.H.M., M.D.M., Z.L., C.S., X.F., C.L.C., S.L., and R.P.B. experiments-design; L.L., A.H.M., M.D.M., Z.L., C.S., X.F. experiments; L.L., A.H.M., M.D.M. data analysis; L.L., A.H.M. writing-original draft; C.C., S.L., R.P.B. materials; A.H.M., R.P.B. writing-review and editing. All authors read and approved the manuscript.
This article contains supplemental data.
Author ORCIDs—Lin Lin https://orcid.org/0000-0003-4702-7190; Carolyn L. Cummins https://orcid.org/0000-0001-7603-6577
Abbreviations—
- ACSF
artificial cerebrospinal fluid
- AEA
arachidonoylethanolamide
- DHEA
docosahexaenoylethanolamide
- EPSC
excitatory postsynaptic current
- E-S
excitation-spike
- FAAH
fatty acid amide hydrolase
- GABA
γ aminobutyric acid
- MSN
medium spiny neuron
- NAE
N-acylethanolamine
- OEA
oleoylethanolamide
- PEA
palmitoylethanolamide
- THA
tetracosahexaenoic acid
- THEA
tetracosahexaenoylethanolamide
- TLE
total lipid extract
Funding and additional information—This study was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) to R.P.B. L.L. was funded by NSERC. S.L., X.F., and M.D.M. were funded by Inrae, Fondation de France, and Nouvelle Région Aquataine. M.D.M. was also funded by Fondation pour la Recherche Médicale.
Conflict of interest—R.P.B. has received research grants from Bunge Ltd., Arctic Nutrition, the Dairy Farmers of Canada, and Nestle Inc., as well as travel support from Mead Johnson and MS equipment and support from SCIEX. In addition, R.P.B. is on the executive board of the International Society for the Study of Fatty Acids and Lipids and held a meeting on behalf of Fatty Acids and Cell Signaling, both of which rely on corporate sponsorship. R.P.B. has given expert testimony in relation to supplements and the brain. R.P.B. also provides complimentary fatty acid analysis for farmers, food producers, and others involved in the food industry, some of whom provide free food samples. The other authors declare that they have no conflicts of interest with the contents of this article.
Manuscript received July 9, 2020, and in revised form August 14, 2020. Published, JLR Papers in Press, August 21, 2020, DOI 10.1194/jlr.RA120001024.
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These authors should be considered co-first authors.