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RESEARCH PAPER
Tobacco Xenobiotics Release Nitric Oxide
1
Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
2
Free Radical & Radiation Biology Graduate Program and Electron Spin Resonance Facility,
The University of Iowa College of Medicine, Iowa City, Iowa, USA
Publication date: 2009-09-15
Corresponding author
EWN Lam
Faculty of Medicine and Dentistry, University of Alberta, DPC 2085, Edmonton, AB T6G 2N8, Canada
Faculty of Medicine and Dentistry, University of Alberta, DPC 2085, Edmonton, AB T6G 2N8, Canada
Tobacco Induced Diseases 2003;1(September):207
KEYWORDS
nicotineElectron Paramagnetic Resonanceelectron paramagnetic resonance spectrumelectron paramagnetic resonance signalsmokeless tobacco
ABSTRACT
Many xenobiotic compounds exert their actions through the release of free
radicals and related oxidants 1,2, bringing about unwanted biological effects 3. Indeed,
oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here,
we demonstrate the direct in vitro release of the free radical nitric oxide (•
NO) from extracts
and components of smokeless tobacco, including nicotine, nitrosonornicotine (NNN) and 4-
(methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in phosphate buffered saline and
human saliva using electron spin resonance and chemiluminescence detection. Our findings
suggest that tobacco xenobiotics represent as yet unrecognized sources of •
NO in the body.
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CITATIONS (7):
1.
Dual-function of thiocyanate on nitrite-induced formation of reactive nitrogen oxide species in human oral cavity: Inhibition under neutral and enhancement under acidic conditions
Umeo Takahama, Kanako Ryu, Takayuki Oniki, Sachiko Hirota
Free Radical Research
Umeo Takahama, Kanako Ryu, Takayuki Oniki, Sachiko Hirota
Free Radical Research
2.
Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats
A. Nirwane, A. Majumdar
Toxicology Research
A. Nirwane, A. Majumdar
Toxicology Research
3.
Smokeless Tobacco Impairs the Antioxidant Defense in Liver, Lung, and Kidney of Rats
Pramod Kumar Avti, Surender Kumar, Chander Mohan Pathak, Kim Vaiphei, Krishan Lal Khanduja
Toxicological Sciences
Pramod Kumar Avti, Surender Kumar, Chander Mohan Pathak, Kim Vaiphei, Krishan Lal Khanduja
Toxicological Sciences
4.
Smokeless tobacco: Risk factor for cardiovascular and breathing in young Indian adolescent
A.K. Choudhary, A. Qudeer
Hipertensión y Riesgo Vascular
A.K. Choudhary, A. Qudeer
Hipertensión y Riesgo Vascular
5.
Smokeless tobacco extract inhibits proliferation and promotes apoptosis in oral mucous fibroblasts
Lei Li, Xiaoqing Zhou, Yanran Wang
Oncology Letters
Lei Li, Xiaoqing Zhou, Yanran Wang
Oncology Letters
6.
The impact of second-hand smoke on nitrogen oxides concentrations in a small interior
Markus Braun, Doris Klingelhöfer, Ruth Müller, David Groneberg
Scientific Reports
Markus Braun, Doris Klingelhöfer, Ruth Müller, David Groneberg
Scientific Reports
7.
Tobacco-related-compound-induced Nitrosative Stress Injury in the Hamster Cheek Pouch
R.D.C. Barley, S. Pollock, M.C. Shallow, E. Peters, E.W.N. Lam
Journal of Dental Research
R.D.C. Barley, S. Pollock, M.C. Shallow, E. Peters, E.W.N. Lam
Journal of Dental Research
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