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Research Article Free access | 10.1172/JCI114801
Whitehead Institute For Biomedical Research, Cambridge, Massachusetts 02142.
Find articles by Tal, M. in: JCI | PubMed | Google Scholar
Whitehead Institute For Biomedical Research, Cambridge, Massachusetts 02142.
Find articles by Schneider, D. in: JCI | PubMed | Google Scholar
Whitehead Institute For Biomedical Research, Cambridge, Massachusetts 02142.
Find articles by Thorens, B. in: JCI | PubMed | Google Scholar
Whitehead Institute For Biomedical Research, Cambridge, Massachusetts 02142.
Find articles by Lodish, H. in: JCI | PubMed | Google Scholar
Published September 1, 1990 - More info
The "erythroid/brain" glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the "liver" GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules. Starvation-dependent expression of the erythroid/brain GT on the plasma membrane of these additional hepatocytes is lost within 3 h of glucose refeeding; however, by immunoblotting we show that the protein is still present. Its loss from the surface is possibly explained by internalization.
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