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Research Article Free access | 10.1172/JCI107366
Endocrine-Metabolism Unit, Monroe Community Hospital, and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14603
Medical Service, St. Luke's Hospital Centerand the Department of Medicine, Columbia University, New York 10025
Find articles by Brodows, R. in: JCI | PubMed | Google Scholar
Endocrine-Metabolism Unit, Monroe Community Hospital, and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14603
Medical Service, St. Luke's Hospital Centerand the Department of Medicine, Columbia University, New York 10025
Find articles by Pi-Sunyer, F. in: JCI | PubMed | Google Scholar
Endocrine-Metabolism Unit, Monroe Community Hospital, and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14603
Medical Service, St. Luke's Hospital Centerand the Department of Medicine, Columbia University, New York 10025
Find articles by Campbell, R. in: JCI | PubMed | Google Scholar
Published August 1, 1973 - More info
The effect of autonomic denervation on the metabolic and hormonal responses during intracellular glucopenia in man was investigated. 2-Deoxy-d-glucose (2 DG), a competitive inhibitor of glucose metabolism, was administered intravenously to nine normal volunteers and to five patients, three with complete cervical cord transection (C-6) and two with idiopathic orthostatic hypotension. Before, during, and after a 20 min infusion of 2 DG (50 mg/kg) plasma concentrations of glucose, lactate, FFA, total catecholamines, immunoreactive insulin (IRI), human growth hormone (HGH), and cortisol were determined for periods up to 150 min. In control subjects, the initial elevation of FFA, glucose. HGH, and cortisol corresponded with the rise in total catecholamines, with maximal levels attained at 60 min, lactate rose at a slower rate, reaching peak levels at 150 min: although no change in IRI was noted. In contrast, 2 DG-induced glucopenic stress in the autonomic denervated subjects was characterized by no detectable catecholamine release or significant rise in glucose, FFA, lactate, or IRI. However, HGH and cortisol responses in four of the five patients were of a similar or greater magnitude than controls.
These studies demonstrate that the integrity of the sympathoadrenomedullary axis is essential for the counter-regulatory response to intracellular glucopenia in man. Cortisol and HGH have no apparent role in these events.
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