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Research Article Free access | 10.1172/JCI105948
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
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Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by Torrance, J. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by English, E. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by Finch, C. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by Reynafarje, C. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by Ramos, J. in: JCI | PubMed | Google Scholar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98105
Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
Find articles by Faura, J. in: JCI | PubMed | Google Scholar
Published December 1, 1968 - More info
The relationship between oxygen dissociation and 2,3-diphosphoglycerate (2,3-DPG) in the red cell has been studied in subjects moving from low to high altitude and vice versa. Within 24 hr following the change in altitude there was a change in hemoglobin affinity for oxygen; this modification therefore represents an important rapid adaptive mechanism to anoxia. A parallel change occurred in the organic phosphate content of the red cell. While this study does not provide direct evidence of a cause-effect relationship, the data strongly suggest that with anoxia, the observed rise in organic phosphate content of the red cell is responsible for increased availability of oxygen to tissues.
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