Synthesis of Mesoporous SBA-16 and SBA-16/ZnO2 Nano-Composite Thin Film for Anti-Biofilm Application
SBA-16 is a mesoporous nanostructure with high surface area and cubic symmetry which make them an ideal carrier to carry different nanoparticles. Zinc peroxide (ZnO2) is a novel nanoparticle that inhibits the growth of microorganisms due to its antiseptic property. Thin film
of SBA-16 and SBA-16/ZnO2 was deposited on glass slide by spin coating method. Anti-biofilm property of the thin films was examined against E. coli and S. aureus bacteria. Structural property was found out by wide angle X-ray diffraction (XRD), small angle X-ray scattering
(SAXS) and High Resolution Transmission Electron Microscope (HRTEM). Fourier Transform Infrared Spectrophotometer (FTIR) was used to confirmation the presence of ZnO2 in Nano-composite and AFM utilized for surface topography of thin films. Fluorescent microscope image clearly revealed
that SBA-16/ZnO2 nanocomposite thin film significantly inhibit the biofilm formation against both E. coli (gram negative bacteria) as well as S. aureus (gram positive bacteria) in comparision to SBA-16. The antimicrobial behavior of ZnO nanoparticle is due to formation
of H2O2 as reactive oxygen species (ROS) to which the bacterial cells are permeable. H2O2 is a powerful oxidizing agents that oxidized the mycobacterial elements like DNA and proteins which results into the toxicity of the bacteria cell.
Keywords: Anti-Biofilm; Antimicrobial Activity; Mesoporous Silica; Nanocomposite; Zinc Oxide
Document Type: Research Article
Affiliations: 1: Materials Science and Nanotechnology, DeenbandhuChhotu Ram University of Science and Technology, Murthal, Sonipat 131039, Haryana, India 2: Bio and Nanotechnology, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India 3: Department of Chemistry, M.K. J.K Mahavidayala, Rohtak 124001, Haryana, India
Publication date: 01 July 2020
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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