Development of Magnetic-Fluorescent Bifunctional Drug Delivery System with Dual Drug Content and Enhanced Fluorescence
The drug delivery system incorporating magnetic particles and fluorescent marker would be uniquely effective for magnetic targeting and fluorescent tracing. In order for the fluorescent signals to reflect the drug delivery accurately, the separation of the fluorescent label and drugs
must be counteracted. The objective of the current study was to design a method of binding drugs to the fluorescent material so that the drug diffusion and delivery could be monitored precisely. To obtain fluorescently-labeled drugs, complexes of the rare earth ion with a single drug benzimidazole
(Tb(Bim)3), and with combined drugs benzimidazole and aspirin (TbBim(Asp)2) were generated. Subsequently, the magnetic nanoparticles Fe3O4 and TbBim(Asp)2 were encapsulated in chitosan microspheres to prepare magnetic fluorescent bifunctional
drug delivery system Fe3O4/TbBim(Asp)2/Chitosan. The intermediate and final products were analyzed by spectroscopy, X-ray diffraction, magnetometry, and electron microscopy, documenting that the newly developed drug-containing nanoparticles exhibited desirable
fluorescent, magnetic, and morphologic properties.
Keywords: Drug Delivery System; Fluorescence; Fluorescently Labeled Dual Drugs Complex; Magnetic Materials
Document Type: Research Article
Affiliations: 1: School of Biological Science and Medical Engineering, Beihang University, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing 100083, China 2: Department of Animal Science, College of Agriculture and Natural Resource, Michigan State University, East Lansing, MI 48824, USA
Publication date: 01 December 2018
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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