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Home / Journal of Nanoscience and Nanotechnology, Volume 16, Number 9

Control of Stem Cell Fate and Function by Polymer Nanofibers

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Stem cells are considered as an integral part of tissue engineering and regenerative medicine. Cellular functions of stem cells, which are responsible for tissue organization, can be controlled and regulated by providing an appropriate microenvironment, which mimics native stem cell niche. Nanotechnology is a powerful tool for engineering cellular microenvironment in the form of scaffolds. The scaffolds that have nanoscale features, for example, nanofiber, are considered as an effective substratum for tissue regenerative applications because they structurally mimic the native extracellular matrix (ECM). Electrospinning is a technique which produces polymer nanofiber scaffolds with controlled size and orientation of the fibrous structure. These polymer nanofibers can be used to control stem cell fate and function, in particular cell adhesion, proliferation and differentiation, during tissue engineering. In this article, we focus on recent developments and research trends in polymer nanofibrous scaffolds and their impact in controlling and regulating stem cell fate and function.

Keywords: Cell-Material Interaction; Nanofibers; Scaffolds; Stem Cells; Tissue Engineering

Document Type: Research Article

Affiliations: 1: Centre for Stem Cell Research (CSCR), A unit of Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru, Christian Medical College Campus, Vellore 632002, India 2: Department of Nanoscience and Technology, Karunya University, Coimbatore 641114, India 3: Department of Orthopedics, Christian Medical College, Hospital Campus, Vellore 632004, India 4: National Centre for Biological Sciences Tata Institute of Fundamental Research, Bangalore 560065, India 5: Centre for Biomaterials Science and Technology, VIT University, SMBS, Vellore 632014, India

Publication date: 01 September 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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