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Home / Journal of Nanoscience and Nanotechnology, Volume 16, Number 8

Preparation of Electrospun Fibrous Scaffold Containing Silver Sulfadiazine for Biomedical Applications

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In this work, we designed an anti-microbial scaffold using polycaprolactone (PCL) polymer blended with silver sulfadiazine (AgSD). This scaffold was prepared by an electrospinning (ELSP) method. The fabricated PCL and AgSD embedded within the PCL fibers were prepared and subsequently characterized using field emission scanning electron microscopy (FE-SEM) with image mapping and thermogravimetric analysis (TGA). In vitro antimicrobial activity of the PCL-AgSD nanofibers was evaluated against Staphylococcus aureus, methicillin-resistant S. aureus, and S. epidermidis. The PCL-AgSD fibers exhibited higher antimicrobial activity against all the tested organisms as compared to control PCL fibers. This design of PCL-AgSD nanofibers holds promise for a wide variety of bio-tissue and bioengineering applications.

Keywords: Antibacterial Effect; Electrospinning; Polycaprolactone; Silver Sulfadiazine

Document Type: Research Article

Affiliations: 1: Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 130-701, Republic of Korea 2: Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon 304-343, Republic of Korea 3: Department of Korean Gynecology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 130-701, Republic of Korea 4: Department of Medical Engineering, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Publication date: 01 August 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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