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Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS)

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Abstract

We have studied the toxicological effects of gas phase cigarette smoke (GPCS) on: 1) lecithin-formed liposome lipid peroxidation; 2) the liposomal membrane fluidity; 3) conformation changes of rat lung cell membrane proteins; and 4) respiratory burst of human polymorphonuclear leukocytes. The results of these investigations suggested that by stimulating lipid peroxidation, GPCS can cause changes of membrane fluidity and alterations of membrane protein conformations as well as damages to membrane-bound enzymes. We conclude that oxidative damage to cells and tissues is an important toxicological property of GPCS.

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Authors and Affiliations

  1. Institute of Biophysics, Academia Sinica, 100080, Beijing

    L. -J. Yan, B. -L. Zhao & W. -J. Xin

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  1. L. -J. Yan
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  2. B. -L. Zhao
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  3. W. -J. Xin
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Yan, L.J., Zhao, B.L. & Xin, W.J. Experimental studies on some aspects of toxicological effects of gas phase cigarette smoke (GPCS). Res Chem Intermed 16, 15–28 (1991). https://doi.org/10.1163/156856791X00156

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  • DOI: https://doi.org/10.1163/156856791X00156

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