Thromb Haemost 2013; 110(06): 1172-1179
DOI: 10.1160/TH13-06-0488
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Non-OO blood type influences the risk of recurrent venous thromboembolism

A cohort study
Esteban Gándara
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
,
Michael J. Kovacs
3   Department of Medicine, University of Western Ontario, London, Ontario, Canada
,
Susan R. Kahn
4   Department of Medicine, McGill University, Montréal, Quebec, Canada
5   Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montréal, Quebec, Canada
,
Philip S. Wells
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
,
David A. Anderson
6   Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
,
Isabelle Chagnon
7   Department of Medicine, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Quebec, Canada
,
Grégoire Le Gal
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
8   UniversityHospital and the Department of Internal Medicine and Chest Diseases, Brest, France
,
Susan Solymoss
4   Department of Medicine, McGill University, Montréal, Quebec, Canada
,
Mark Crowther
9   Department of Medicine, Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada
,
Marc Carrier
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
,
Nicole Langlois
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
,
Judy Kovacs
3   Department of Medicine, University of Western Ontario, London, Ontario, Canada
,
Julian Little Ma
10   Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
,
Nancy Carson
11   Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
,
Tim Ramsay
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
10   Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
,
Marc A. Rodger
1   Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2   Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa, Ontario, Canada
› Author Affiliations
Financial support: This study was funded by the Canadian Institutes of Health Research (grants no. MOP102510 and64319), the Heart and Stroke Foundation (grant NA 6771) and BioMérieux (through an unrestricted research grant).
Further Information

Publication History

Received: 14 June 2013

Accepted after major revision: 16 August 2013

Publication Date:
30 November 2017 (online)

Summary

The role of ABO blood type as a risk factor for recurrent venous thromboembolism (VTE) in patients with a first unprovoked VTE who complete oral anticoagulation therapy is unknown. The aim of this study was to determine if non-OO blood type is a risk factor for recurrent VTE in patients with a first unprovoked VTE who completed 5–7 months of anticoagulant therapy. In an ongoing cohort study of patients with unprovoked VTE who discontinued oral anticoagulation after 5–7 months of therapy, six single nucleotide polymorphisms sites were tested to determine ABO blood type using banked DNA. The main outcome was objectively proven recurrent VTE. Mean follow-up for the cohort was 4.19 years (SD 2.16). During 1,553 patient-years of follow-up, 101 events occurred in 380 non-OO patients (6.5 events per 100 patient years; 95% CI 5.3–7.7) compared to 14 events during 560 patient years of follow-up in 129 OO patients (2.5 per 100 patient years; 95% CI 1.2–3.7), the adjusted hazard ratio was 1.98 (1.2–3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE.

 
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