Roles of Cholesterol and Lipids in the Etiopathogenesis of
Alzheimer's Disease

Rojo, Leonel; Sjöberg, Marcela K.; Hernández, Paula; Zambrano, Cristian; Maccioni, Ricardo B.

doi:https://doi.org/10.1155/JBB/2006/73976

BioMed Research International

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Neurodegenerative Diseases: Mechanisms and Therapies

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Review Article | Open Access

Volume 2006 | Article ID 073976 | https://doi.org/10.1155/JBB/2006/73976

Roles of Cholesterol and Lipids in the Etiopathogenesis of Alzheimer's Disease

Leonel Rojo,^1,2Marcela K. Sjöberg,^1,3Paula Hernández,^1,3Cristian Zambrano,^1,3and Ricardo B. Maccioni^1,3

Received02 Dec 2005

Revised25 May 2006

Accepted30 May 2006

Published05 Jul 2006

Abstract

Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies.This brain disorder is characterized by the formation of brain protein aggregates, namely, the paired helical filaments and senile plaques. Oxidative stress during life, neuroinflamamtion, and alterations in neuron-glia interaction patterns have been also involved in the etiopathogenesis of this disease. In recent years, cumulative evidence has been gained on the involvement of alteration in neuronal lipoproteins activity, as well as on the role of cholesterol and other lipids in the pathogenesis of this neurodegenerative disorder. In this review, we analyze the links between changes in cholesterol homeostasis, and the changes of lipids of major importance for neuronal activity and Alheimer's disease. The investigation on the fine molecular mechanisms underlying the lipids influence in the etiopathogenesis of Alzheimer's disease may shed light into its treatment and medical management.

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Copyright © 2006 Leonel Rojo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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