Abstract
Wolbachia, an endosymbiotic bacterium
found in most species of filarial parasites, is thought to play a significant
role in inducing innate inflammatory responses in lymphatic filariasis
patients. However, the Wolbachia-derived molecules
that are recognized by the innate immune system have not yet been
identified. In this study, we exposed the murine macrophage cell line
RAW 264.7 to a recombinant form of the major Wolbachia
surface protein (rWSP) to determine if WSP is capable of innately inducing
cytokine transcription. Interleukin (IL)-1